The 15 Most Common Food Additives — What Each One Actually Does
The FDA's database of substances added to food lists over 3,900 additives. Most Americans regularly consume fewer than 20 of them. This guide covers the 15 you are most likely to encounter, with safety ratings grounded in FDA and EFSA data — not headlines.
How to read this list
How food additives are approved in the US
Under the Federal Food, Drug, and Cosmetic Act, any substance intentionally added to food must either be approved by the FDA through a formal petition process or be classified as Generally Recognized as Safe (GRAS). GRAS status can be self-determined by manufacturers — a process that has drawn criticism from consumer advocacy groups for its lack of mandatory FDA review. The EU operates a stricter pre-market authorization system under Regulation (EC) No 1333/2008, which is why several additives approved in the US are not permitted in the EU, and vice versa.
For a practical guide to decoding ingredient labels, see How to Read Food Labels: A Parent's Guide to Additives.
The 15 most common food additives, ranked by prevalence
Preservatives
Preservative
Used in acidic beverages (sodas, juices) to inhibit yeast and mold growth. When combined with ascorbic acid (vitamin C) in the same product, it can form benzene — a known carcinogen — at trace levels. A 2007 Southampton University study also linked it to hyperactivity in children when combined with certain food dyes.
Preservative
A salt of sorbic acid, potassium sorbate inhibits mold and yeast in cheese, wine, yogurt, and dried fruit. It is among the most extensively studied food preservatives. EFSA and FDA both consider it safe at current use levels. Some rare contact allergy cases have been documented.
Acidulant / Preservative
Produced by bacterial fermentation, lactic acid is the compound responsible for the tang in yogurt, sauerkraut, and sourdough. Used commercially to extend shelf life and control pH. FDA GRAS. Naturally occurring in the human body as a metabolic byproduct; no concerns at food-use levels.
Antioxidants
Antioxidant / Vitamin C
Naturally found in citrus fruit, ascorbic acid is used to prevent browning and extend shelf life. It is also a mandatory co-additive in cured meats to reduce nitrosamine formation. FDA GRAS. No adverse effects at typical food-use levels.
Antioxidant / Preservative
BHA prevents fat oxidation in snack foods, cereals, and butter. It is listed as a possible human carcinogen by IARC (Group 2B) based on animal studies showing tumor formation at high doses. The US National Toxicology Program classifies it as 'reasonably anticipated to be a human carcinogen.' Still FDA GRAS — a status that has drawn criticism from public health researchers.
Antioxidant / Preservative
Often used alongside BHA, BHT extends the shelf life of fats and oils in packaging materials and cereals. Evidence for carcinogenicity is less clear than with BHA — some animal studies show tumor promotion, others suggest anticarcinogenic effects. FDA GRAS. EFSA permits use at low levels. Classified as a possible endocrine disruptor in some independent reviews.
Thickeners and Emulsifiers
Thickener / Stabilizer
A polysaccharide produced by fermenting Xanthomonas campestris bacteria on glucose. It thickens salad dressings, sauces, and gluten-free baked goods. FDA GRAS. Well-tolerated in most people; very high doses can cause digestive discomfort in sensitive individuals.
Emulsifier
Extracted from soybean oil as a byproduct of processing, soy lecithin keeps chocolate from separating and improves texture in baked goods. Most soy proteins — the allergenic fraction — are removed during extraction; residual protein levels are generally too low to trigger reactions in soy-allergic individuals, though severe allergy warrants caution.
Thickener / Gelling Agent
Extracted from red seaweed, carrageenan is used in dairy products, infant formula, and processed meats. Undegraded carrageenan (food-grade) is approved by FDA, but some studies on degraded carrageenan (poligeenan) show inflammatory effects in animal models. IARC classified poligeenan as possibly carcinogenic (Group 2B). The debate about whether food-grade carrageenan poses any human risk remains active in the literature.
Acidulants
Acidulant / Preservative / Flavor
One of the most widely used food additives globally, citric acid acidifies beverages, preserves canned foods, and enhances tart flavors. Produced commercially by fermenting Aspergillus niger mold on sugar substrates. FDA GRAS. Well-tolerated except in rare mold-sensitive individuals.
Sweeteners and Sugar Replacers
Bulking Agent / Carrier
A highly processed starch derivative with a glycemic index higher than table sugar, maltodextrin is used to bulk out powdered foods, instant sauces, and sports supplements. It contributes to caloric density without sweetness. No acute safety concerns, but research links high-GI diets to metabolic risk — relevant for diabetics and prediabetics.
Sweetener
HFCS is produced by enzymatically converting corn starch glucose to fructose. It is nutritionally similar to sucrose but metabolized differently — fructose bypasses insulin regulation and is processed primarily in the liver. High intake is associated with non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and insulin resistance in clinical studies, though causation is debated. FDA GRAS.
Artificial Sweetener
Aspartame is approximately 200 times sweeter than sugar and is used in diet beverages, tabletop sweeteners, and reduced-sugar foods. In July 2023, the WHO's IARC classified it as a possible carcinogen (Group 2B), based on limited evidence from observational studies. The same month, JECFA (WHO/FAO) maintained the ADI at 40 mg/kg/day, stating the evidence was insufficient to change safety limits. Individuals with phenylketonuria (PKU) must avoid it entirely.
Flavor Enhancers and Synthetic Dyes
Flavor Enhancer (Umami)
MSG enhances savory taste by stimulating glutamate receptors. It occurs naturally in tomatoes, parmesan, and soy sauce. FDA classifies it as GRAS. Double-blind studies have not confirmed the anecdotal 'Chinese Restaurant Syndrome.' EFSA set an ADI of 30 mg/kg/day in 2017 and noted that typical dietary exposure is below this threshold for most adults.
Synthetic Food Dye
One of the most widely used synthetic dyes in US food, Red 40 colors candies, cereals, beverages, and maraschino cherries. The 2007 Southampton study linked it (in a mix with other dyes and sodium benzoate) to increased hyperactivity in children. The EU requires a warning label on products containing it. The FDA reviewed the evidence in 2011 and did not mandate a label change, concluding the data was not sufficient to establish causation.
2024 — 2026 regulatory updates
Red 40 and food dyes: The FDA announced a phased review of synthetic food dyes in 2024 following California's Food Safety Act (AB 418), which requires reformulation or warning labels on products containing six dyes including Red 40 starting 2027.
BHA: The National Toxicology Program completed an updated carcinogen review in 2024, maintaining BHA's classification as "reasonably anticipated to be a human carcinogen."
Which additives appear most in ultra-processed foods?
Research published in JAMA Internal Medicine (2021) found that ultra-processed foods — products high in additives, low in whole-food ingredients — accounted for 57% of energy intake in the average US diet. The additives most consistently present across ultra-processed categories are maltodextrin, high fructose corn syrup, citric acid, sodium benzoate, BHT, Red 40, and artificial sweeteners including aspartame.
The concern with ultra-processed foods is less about any single additive and more about the cumulative pattern of consumption. No individual additive in this list — at typical exposure levels — has been demonstrated to cause acute harm in healthy adults. The epidemiological associations emerge at population scale, at high consumption levels, over years.
For a deeper look at two of the most debated items on this list, see our guides on the real science behind MSG and what the 2023 aspartame ruling actually means.
Frequently asked questions
Which food additives should I avoid?
The additives with the most documented concerns are BHA (E320), BHT (E321), Red 40 (E129), and carrageenan (E407). BHA is classified as a possible human carcinogen by IARC. Red 40 has been linked to hyperactivity in sensitive children in EFSA-reviewed studies. That said, 'avoid' depends on your individual health context. Consulting a registered dietitian is more useful than blanket avoidance.
Are food additives regulated?
Yes. In the US, the FDA regulates food additives under 21 CFR. Additives must be approved before use, except for substances designated GRAS (Generally Recognized as Safe). In the EU, the European Food Safety Authority (EFSA) reviews and authorizes additives under Regulation (EC) No 1333/2008. Standards differ between jurisdictions — some additives approved in the US are restricted or banned in the EU.
What is the most harmful food additive?
There is no single answer — harm depends on dose, individual sensitivity, and cumulative exposure. BHA is classified as a possible carcinogen (IARC Group 2B). Partially hydrogenated oils (trans fats) were banned by the FDA in 2018 after strong evidence linking them to cardiovascular disease. Aspartame was reclassified as a possible carcinogen (IARC Group 2B) in 2023, though JECFA maintained its ADI at 40 mg/kg/day.
How do I read a food additive label?
In the US, additives appear in the ingredients list in descending order by weight. E-numbers (e.g., E330, E211) are used in the EU; US labels use common names (citric acid, sodium benzoate). To decode an ingredient: search it on Additive Facts by name or E-number. Look at the safety rating, the FDA/EFSA regulatory status, and any documented adverse reactions.
Disclaimer
This article is for informational purposes only and does not constitute medical or dietary advice. Safety ratings reflect current regulatory assessments from FDA and EFSA and may not account for individual sensitivities or medical conditions. Consult a qualified healthcare professional before making dietary changes based on this information.
Related guides
Sources
- US FDA. 'Everything Added to Food in the United States (EAFUS).' FDA Substances Added to Food database.
- European Food Safety Authority (EFSA). 'Food additives.' EFSA Journal, various years. efsa.europa.eu/en/topics/topic/food-additives
- IARC Working Group. 'IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.' Volumes 73, 101, 132.
- JECFA (Joint WHO/FAO Expert Committee on Food Additives). 'Evaluation of aspartame.' 96th meeting, 2023.
- Monteiro CA et al. 'Ultra-processed foods: what they are and how to identify them.' Public Health Nutrition, 2019.
- Chazelas E et al. 'Food additive emulsifiers and risk of cardiovascular disease in the NutriNet-Santé cohort.' BMJ, 2023.
- McCann D et al. 'Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children.' The Lancet, 2007.
Deep dive into these ingredients
Full safety profiles, E-numbers, and regulatory status — updated monthly.