4,8-dimethyl-3,7-nonadien-2-one, Cis-

4,8-dimethyl-3,7-nonadien-2-one, Cis- is a synthetic organic compound classified as a flavoring agent. With CAS number 27575-61-7, it belongs to the family of terpene-derived compounds commonly used in the fragrance and food industries. The compound has a nonadiene structure with methyl substituents and a ketone functional group, contributing to its aromatic properties. It exists in a specific cis-configuration, which influences its sensory characteristics and biological activity.

This flavoring agent is primarily used in the food and beverage industry to create fruity, slightly floral, and herbal flavor profiles. It may be incorporated into products such as beverages, confectionery, baked goods, dairy products, and flavor compounds. The compound's fruity character makes it useful in formulations targeting tropical or berry-like flavor notes. As a flavoring adjuvant, it works in combination with other flavor ingredients to enhance or modulate overall taste and aroma profiles in food products.

According to FDA records, there have been zero adverse events and zero recalls associated with 4,8-dimethyl-3,7-nonadien-2-one, Cis-. This suggests no safety signals or consumer complaints have been documented in the United States food supply. The compound has not received FDA GRAS (Generally Recognized as Safe) status, which indicates it either has not undergone formal GRAS notification or has not met the criteria for that designation. However, the absence of GRAS status does not necessarily indicate the substance is unsafe; rather, it reflects the regulatory pathway and notification status with the FDA.

Limited published toxicological data is available in the scientific literature specific to this exact isomer. Many terpene-derived flavoring compounds have long histories of safe use in food at very low concentrations, typically in the parts-per-million range. The absence of reported adverse events in the FDA database is a positive safety indicator for real-world use in food applications.

In the United States, this compound's regulatory status is not as a GRAS substance. This means any manufacturer using it would need to comply with FDA regulations for food additives, including proper listing and compliance with applicable food additive regulations. The compound may be used in other jurisdictions under different regulatory frameworks. The European Food Safety Authority (EFSA) maintains separate evaluation procedures for flavoring compounds, and regulatory status may vary between the EU and United States.

Manufacturers and formulators should verify current regulatory permissions in their specific markets before use, as regulations regarding flavoring compounds can evolve and may differ by country or region.

Specific published safety studies or toxicological assessments exclusively focused on this particular isomer (4,8-dimethyl-3,7-nonadien-2-one, Cis-) are limited in the publicly available scientific literature. Most safety data for related terpene flavoring compounds comes from broader studies on volatile flavor components and their metabolic pathways. The chemical structure suggests metabolic similarity to other naturally occurring and synthetic terpene compounds that have been extensively studied.

The lack of adverse events in FDA databases over the period of its use in food applications provides real-world evidence of safety at approved usage levels. For the most current safety assessments, regulatory bodies like the FDA and EFSA maintain comprehensive databases of flavoring compound evaluations, though specific detailed studies on this isomer may be proprietary or limited in scope.