# (z)-3-hexenyl Valerate

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> Markdown URL: https://additivefacts.com/additives/z-3-hexenyl-valerate.md

**Safety rating:** UNKNOWN
**CAS number:** 35852-46-1
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

(Z)-3-hexenyl valerate is a synthetic flavoring compound used to impart fruity and green notes to food products. It is not approved as a Generally Recognized as Safe (GRAS) substance by the FDA but has no reported adverse events or recalls.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is (Z)-3-hexenyl Valerate?

(Z)-3-hexenyl valerate, identified by CAS number 35852-46-1, is a synthetic organic ester belonging to the class of compounds known as volatile flavor compounds. It is chemically composed of a valeric acid (5-carbon chain) moiety esterified with a (Z)-3-hexenol molecule, which creates a compound with distinctive fruity and fresh, green-leaf characteristics. The "Z" designation indicates the geometric configuration of a double bond within the hexenol portion of the molecule, which is critical to its sensory properties.

## Common Uses

This compound is utilized primarily in the flavor industry as a flavoring agent and flavor adjuvant. It is typically incorporated into beverages, confectionery products, baked goods, and other processed foods where fruity or fresh green notes are desired. The compound contributes subtle, complex flavor profiles that complement both sweet and savory food matrices. Its use is concentrated in industrialized food production, particularly in the creation of artificial fruit and botanical flavor formulations. Due to its volatile nature, it is often employed in products where fresh, top-note aromatics enhance consumer appeal.

## Safety Assessment

The safety profile of (Z)-3-hexenyl valerate remains limited in scope, as comprehensive toxicological data are not extensively published in readily accessible scientific literature. The FDA has not granted this substance GRAS status, meaning it has not been formally recognized as safe for use in food through established safety precedent or expert consensus review. However, the absence of reported adverse events or FDA recalls indicates that documented harm from this compound in food applications has not been established. The lack of adverse event reports suggests either low exposure levels, minimal toxicological concern, or limited regulatory scrutiny. As with many synthetic flavor compounds, safety assessments typically rely on structural analogs and limited in vitro or animal studies rather than extensive human clinical data.

## Regulatory Status

In the United States, (Z)-3-hexenyl valerate does not hold GRAS status and therefore operates under the jurisdiction of FDA regulations for food additives. Its use would technically require food additive approval, though enforcement practices vary. The compound may be used in the European Union under the flavor regulations (EC) No. 1334/2008, as it appears on approved flavor substance lists. The International Organization for Standardization (ISO) and the Flavor and Extract Manufacturers Association (FEMA) may recognize this compound within their flavor chemical guidelines. Regulatory approval status varies by country, and manufacturers should verify compliance with regional regulations before use.

## Key Studies

Limited peer-reviewed safety data are publicly available specifically for (Z)-3-hexenyl valerate. Most information regarding its safety derives from structure-activity relationship assessments based on similar ester compounds and volatile organic compounds (VOCs) used in food flavoring. General toxicological data on related valerate esters and hexenol derivatives suggest these compounds are metabolized through standard esterase pathways and eliminated efficiently in mammals. The absence of chronic toxicity studies in published literature reflects the regulatory framework for flavor chemicals, where safety is often presumed based on chemical class membership, historical use patterns, and structural comparison rather than comprehensive individual testing. Future safety assessments would benefit from controlled studies evaluating genotoxicity, developmental toxicity, and long-term exposure effects at typical dietary exposure levels.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "(z)-3-hexenyl Valerate — Safety, regulation, and evidence." https://additivefacts.com/additives/z-3-hexenyl-valerate. Accessed 2026-05-19.