# Vitamin B Complex And Syrup

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> Markdown URL: https://additivefacts.com/additives/vitamin-b-complex-and-syrup.md

**Safety rating:** SAFE
**CAS number:** 977154-08-7
**Category:** nutrient
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-04

## Summary

Vitamin B Complex and Syrup is a nutrient supplement formulation combining B vitamins with a syrup base, used to fortify food and beverage products. It provides essential B vitamins including thiamine, riboflavin, niacin, and other B vitamins that support energy metabolism and cellular function.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | approved |
| Canada | approved |
| Australia | approved |
| Japan | approved |
| South Korea | approved |
| Brazil | approved |
| China | approved |
| India | approved |

## Detailed analysis

## What is Vitamin B Complex and Syrup?

Vitamin B Complex and Syrup is a liquid nutrient formulation that combines multiple B vitamins suspended or dissolved in a syrup vehicle. The B-complex group includes water-soluble vitamins such as thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). The syrup component serves as a carrier and preservative medium, facilitating easier incorporation into liquid and semi-liquid food products.

## Common Uses

This nutrient supplement is primarily used in food fortification and enrichment applications. Common applications include:

- Breakfast cereals and grain-based products
- Nutritional beverage formulations
- Functional drinks and sports beverages
- Dairy and plant-based milk alternatives
- Ready-to-drink nutritional supplements
- Infant and pediatric nutritional formulas

The syrup formulation allows manufacturers to achieve uniform distribution of B vitamins throughout products and provides a convenient liquid form for mixing during production. B vitamins are essential micronutrients that support energy metabolism, nervous system function, and red blood cell formation.

## Safety Assessment

Vitamin B Complex and Syrup has not been formally designated as Generally Recognized as Safe (GRAS) by the FDA. However, the individual B vitamins contained within this formulation have well-established safety profiles. B vitamins are water-soluble and excess amounts are typically excreted in urine, making toxicity from dietary sources uncommon.

According to FDA records, there have been zero adverse events reported specifically associated with this additive, and zero product recalls initiated due to this ingredient. The absence of reported safety concerns reflects decades of safe use of B vitamins in food fortification globally.

Individual B vitamins have established tolerable upper intake levels (ULs) set by the National Academies of Sciences, Engineering, and Medicine. For example, niacin has a UL of 35 mg/day for adults due to potential flushing at very high intakes, while most other B vitamins lack established ULs due to low toxicity risk from food sources.

## Regulatory Status

While Vitamin B Complex and Syrup itself is not GRAS-designated, it may be used in foods under FDA regulations as a nutrient supplement when the individual B vitamins meet their respective regulatory requirements. The FDA permits B vitamin fortification and enrichment of foods under 21 CFR Part 104 for bakery products and 21 CFR Part 137 for cereal grain products.

Europe's EFSA has evaluated B vitamins extensively and confirmed their safety at supplemental levels for the general population. Maximum levels for vitamin fortification are established in EU Regulation 1925/2006 to prevent excessive intakes.

## Key Studies

Extensive research documents the safety and efficacy of B vitamins in food fortification. Large population studies demonstrate that B vitamin fortification effectively prevents deficiency diseases such as beriberi (thiamine), pellagra (niacin), and neural tube defects (folate). Meta-analyses of B vitamin supplementation trials consistently show favorable safety profiles across diverse populations.

The stability and bioavailability of B vitamins in syrup formulations have been validated in multiple food science studies, confirming that the syrup vehicle does not compromise vitamin stability or absorption. Research on combined B-complex formulations demonstrates no significant adverse interactions between individual B vitamins at fortification levels.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Vitamin B Complex And Syrup — Safety, regulation, and evidence." https://additivefacts.com/additives/vitamin-b-complex-and-syrup. Accessed 2026-05-20.