# Tridodecyl Amine

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**Safety rating:** UNKNOWN
**CAS number:** 102-87-4
**Category:** solvent
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-04

## Summary

Tridodecyl amine is a long-chain aliphatic amine compound used as a solvent and vehicle in food processing. It functions to dissolve or disperse other substances in food manufacturing applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | approved |
| Canada | approved |
| Australia | approved |
| Japan | approved |
| South Korea | approved |
| Brazil | approved |
| China | approved |
| India | approved |

## Detailed analysis

## What is Tridodecyl Amine?

Tridodecyl amine (CAS Number 102-87-4) is a synthetic organic compound belonging to the amine family of chemicals. It consists of a nitrogen atom bonded to three dodecyl (12-carbon) alkyl chains, making it a tertiary amine with significant lipophilic (fat-soluble) properties. The compound appears as a liquid or semi-solid at room temperature and is primarily utilized in industrial and food manufacturing contexts.

## Common Uses

Tridodecyl amine functions as a solvent and vehicle in food processing applications. Solvents and vehicles are substances used to dissolve, disperse, or extract other compounds during food manufacture, and they may be removed during processing or remain in trace amounts in the final product. Due to its chemical structure, tridodecyl amine can solubilize both polar and nonpolar substances, making it useful in the formulation of certain food additives, flavorings, colorants, and processing aids. Its specific applications include use in pesticide formulations that may contact food surfaces and in extraction processes during food ingredient preparation.

## Safety Assessment

Tridodecyl amine has not been granted Generally Recognized As Safe (GRAS) status by the U.S. Food and Drug Administration. However, this designation reflects the lack of formal GRAS approval rather than established safety concerns. According to FDA records, there are zero reported adverse events associated with tridodecyl amine and zero product recalls involving this substance, indicating no documented consumer health incidents in the United States food supply.

Limited toxicological data is publicly available for this specific compound. Available studies suggest that tridodecyl amine exhibits low acute toxicity when administered orally in animal models. The long-chain alkyl structure suggests potential for bioaccumulation, though the significance of this for food safety remains unclear due to the typically small amounts used in processing and the likelihood of removal or degradation before food consumption.

The chemical's behavior in food systems depends on processing conditions and its concentration. As with all processing solvents, regulatory frameworks require that residual amounts in finished foods be at or below safety thresholds established based on toxicological data.

## Regulatory Status

Tridodecyl amine is not currently listed on the FDA's GRAS list as of the latest available information. In the United States, its use in foods is permitted only through specific regulatory pathways—either as a component of an approved food additive petition or under the direct food additive regulations (21 CFR Part 173). When used as a solvent in pesticide formulations for pre-harvest applications, it falls under pesticide regulation via the Environmental Protection Agency (EPA).

The European Food Safety Authority (EFSA) has not published detailed assessments specific to tridodecyl amine in food applications, though the chemical is regulated under EU regulations for processing aids and solvents (Regulation EC No 1333/2008).

The absence of GRAS status does not prohibit use; rather, it indicates that the compound requires specific authorization before use in food manufacturing. Food manufacturers using this substance must have documented evidence of safety and must comply with applicable regulations in their jurisdiction.

## Key Studies

Published scientific literature on tridodecyl amine's safety in food applications is limited. Most available toxicological data derives from industrial chemical databases and occupational safety resources rather than food-specific research. Studies on structurally similar long-chain amines indicate that these compounds generally exhibit low acute oral toxicity but warrant evaluation for chronic exposure and potential bioaccumulation.

The lack of FDA adverse events and recalls associated with tridodecyl amine suggests that if used in food manufacturing, current practices maintain safety margins. However, additional peer-reviewed studies specifically evaluating its use as a food processing solvent would provide stronger scientific foundation for regulatory confidence.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Tridodecyl Amine — Safety, regulation, and evidence." https://additivefacts.com/additives/tridodecyl-amine. Accessed 2026-05-20.