# Trans-3-hexenol

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> Markdown URL: https://additivefacts.com/additives/trans-3-hexenol.md

**Safety rating:** UNKNOWN
**CAS number:** 928-97-2
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-04

## Summary

Trans-3-hexenol is a naturally occurring volatile compound used as a flavoring agent in food products. It provides grassy, herbaceous, and fruity flavor notes and is derived from or chemically synthesized to replicate compounds found in fresh plants and fruits.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | approved |
| Canada | approved |
| Australia | approved |
| Japan | approved |
| South Korea | approved |
| Brazil | approved |
| China | approved |
| India | approved |

## Detailed analysis

## What is Trans-3-hexenol?

Trans-3-hexenol (CAS Number 928-97-2) is a six-carbon alcohol with a double bond in the trans configuration. It is a volatile organic compound found naturally in various plants, fruits, and vegetables, including tomatoes, grapes, and leafy greens. The compound is colorless to pale yellow and has a characteristic fresh, green, herbaceous aroma with fruity undertones. In food manufacturing, trans-3-hexenol is produced through chemical synthesis to create consistent, standardized flavoring ingredients.

## Common Uses

Trans-3-hexenol is primarily used as a flavoring agent in the food and beverage industry. Its applications include:

- Alcoholic beverages (wines, spirits, craft beers)
- Non-alcoholic beverages (fruit juices, soft drinks)
- Flavored dairy products (yogurts, cheese spreads)
- Baked goods and confectionery items
- Savory snacks and prepared foods
- Flavor compositions for processed fruits and vegetables

The compound contributes fresh, grassy, and fruity notes that enhance the perceived naturalness and complexity of food products. Flavorists use trans-3-hexenol in very small quantities, typically measured in parts per million, to achieve desired sensory profiles without imparting off-flavors.

## Safety Assessment

Trans-3-hexenol has not been formally evaluated or approved by the FDA under the Generally Recognized as Safe (GRAS) program. However, the absence of GRAS status does not indicate the substance is unsafe. Instead, it reflects the regulatory pathway and extent of safety evaluation conducted.

Key safety observations include:

- Zero adverse events reported to the FDA
- Zero recalls associated with trans-3-hexenol
- Natural occurrence in edible plants suggests a degree of safety at dietary levels
- The compound is volatile and used in minimal concentrations in finished food products
- As a small molecular weight alcohol, it is readily absorbed and metabolized

The European Food Safety Authority (EFSA) has evaluated structurally related flavor compounds under Regulation (EC) No 1334/2008 on food flavorings. While trans-3-hexenol may not be specifically listed in current EU flavor inventories, similar C6 volatile alcohols have undergone risk assessment and been found acceptable when used as intended.

## Regulatory Status

Trans-3-hexenol's regulatory standing varies internationally:

- **United States**: Not GRAS-listed; may be used under FDA's food additive petition process or in products where it qualifies under different regulatory frameworks
- **European Union**: Subject to Regulation (EC) No 1334/2008; status depends on inclusion in the Union List of approved flavoring substances
- **Other jurisdictions**: Status varies; some countries may permit it under general flavor provisions while others require specific approval

Manufacturers using trans-3-hexenol must ensure compliance with applicable regulations in their target markets. The lack of GRAS status in the United States may limit its use compared to approved alternatives, though it may still be permitted in certain food categories or under specific regulatory allowances.

## Key Studies

Scientific literature on trans-3-hexenol is limited compared to more widely used flavor compounds. Research has focused on:

- **Sensory profiling studies**: Characterizing the flavor contributions of C6 volatile alcohols in wine and fruit systems
- **Metabolic studies**: Understanding absorption and metabolism of similar volatile alcohols in humans
- **Natural occurrence**: Identifying trans-3-hexenol levels in fresh produce and plant materials
- **Chemical synthesis**: Optimizing production methods for food-grade flavor ingredients

The compound's limited regulatory evaluation does not reflect safety concerns but rather reflects lower commercial demand compared to other flavoring agents. Published toxicology data specific to trans-3-hexenol is sparse, though structural analogs have been evaluated as part of broader EFSA flavor assessments.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Trans-3-hexenol — Safety, regulation, and evidence." https://additivefacts.com/additives/trans-3-hexenol. Accessed 2026-05-20.