# Starch, Food, Modified: Isoamylase Modified Starch

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**Safety rating:** UNKNOWN
**CAS number:** 977186-03-0
**Category:** other
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-04

## Summary

Isoamylase Modified Starch is a chemically modified food starch created through enzymatic treatment with isoamylase, an enzyme that alters starch's molecular structure. Its specific functional properties and primary applications in food manufacturing remain poorly documented in publicly available scientific literature.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | approved |
| Canada | approved |
| Australia | approved |
| Japan | approved |
| South Korea | approved |
| Brazil | approved |
| China | approved |
| India | approved |

## Detailed analysis

## What is Starch, Food, Modified: Isoamylase Modified Starch?

Isoamylase Modified Starch is a food-grade starch that has undergone enzymatic modification using isoamylase, an enzyme classified as a debranching enzyme. Isoamylase specifically cleaves alpha-1,6-glycosidic bonds in the starch molecule, which are the branch points in amylopectin. This enzymatic treatment alters the physical and chemical properties of the native starch, creating a modified ingredient with characteristics distinct from unmodified starch.

The CAS number 977186-03-0 identifies this specific modified starch formulation in chemical databases. Modified starches are commonly used throughout the food industry to improve texture, stability, and processing characteristics of various food products.

## Common Uses

While the specific applications of isoamylase-modified starch are not extensively documented in public databases, modified starches in general serve multiple functions in food manufacturing. These applications typically include:

Thickening agents in sauces, gravies, and soups; stabilizers in dairy products and salad dressings; binders in processed meat products; texture improvers in baked goods; and film-forming agents in certain food applications. The debranching action of isoamylase treatment would theoretically create a starch with altered viscosity and gel properties compared to native starch.

The limited public information about this specific modification suggests it may be used in specialized applications or by a limited number of manufacturers, or its functional benefits may be proprietary knowledge.

## Safety Assessment

According to the FDA database, there are zero recorded adverse events associated with this additive and zero product recalls linked to its use. This absence of reported safety incidents suggests either a strong safety profile or minimal market presence.

Starch-based ingredients, whether modified or unmodified, are generally recognized as safe by regulatory bodies when used appropriately. The enzymatic modification process using isoamylase does not introduce new chemical entities beyond what occurs naturally during starch digestion and metabolism. Isoamylase itself is derived from naturally occurring enzymes and is not a synthetic chemical.

Starch and modified starch products are among the most widely consumed food additives globally, with extensive historical use supporting their general safety when used as intended. However, the specific toxicological data for this particular isoamylase-modified formulation is not readily available in peer-reviewed literature or FDA databases.

## Regulatory Status

This additive does not currently hold FDA GRAS (Generally Recognized As Safe) status. This designation does not necessarily indicate safety concerns; rather, it means formal GRAS notification or affirmation has not been completed or published for this specific modification.

Modified starches are regulated under FDA regulations 21 CFR Part 182 (indirect food additives) and Part 184 (direct food additives). The specific regulatory pathway and approval status for isoamylase-modified starch may vary by country and intended use.

The lack of GRAS status combined with zero recorded adverse events suggests this ingredient may have limited commercial use, may be in earlier stages of market development, or may be used in specific food applications subject to different regulatory frameworks.

## Key Studies

Published peer-reviewed research specifically examining isoamylase-modified starch safety and functionality is limited in public databases. Most available scientific literature on isoamylase focuses on its enzymatic properties in laboratory and industrial starch processing contexts rather than consumer safety assessments.

Broader research on modified starches demonstrates that enzymatic modifications generally do not create safety concerns when the enzymes are inactivated during processing and the final product composition is established. Standard toxicological principles suggest that debranched starches would be readily digestible and unlikely to pose systemic toxicity risks.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Starch, Food, Modified: Isoamylase Modified Starch — Safety, regulation, and evidence." https://additivefacts.com/additives/starch-food-modified-isoamylase-modified-starch. Accessed 2026-05-20.