# S-ethyl 2-acetylaminoethanethioate

> Source URL: https://additivefacts.com/additives/s-ethyl-2-acetylaminoethanethioate
> Markdown URL: https://additivefacts.com/additives/s-ethyl-2-acetylaminoethanethioate.md

**Safety rating:** UNKNOWN
**CAS number:** 4396-62-7
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

S-ethyl 2-acetylaminoethanethioate (CAS 4396-62-7) is a synthetic flavoring compound used to impart savory, meaty, or umami-like taste characteristics in food products. This sulfur-containing molecule functions as a flavoring agent or adjuvant in processed foods.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is S-ethyl 2-acetylaminoethanethioate?

S-ethyl 2-acetylaminoethanethioate is a synthetic organic compound classified as a flavoring agent. Its chemical structure contains an acetamide group linked to a thioester moiety, making it a sulfur-containing molecule. The compound is identified by CAS Number 4396-62-7 in chemical databases. As a synthetic flavoring, it is manufactured through chemical synthesis rather than derived from natural sources, though it may be designed to mimic or enhance naturally occurring flavor profiles.

## Common Uses

This additive is used in the flavor industry as a flavoring agent or adjuvant, typically in processed foods where savory, meaty, or umami-enhancing taste profiles are desired. Like other synthetic flavor compounds, it would typically be used in very small quantities measured in parts per million (ppm). The compound may appear in formulations for meat analogs, savory snacks, broths, sauces, or other foods where umami or savory flavor enhancement is desired. Its specific sensory profile and application rates would be determined by flavor manufacturers during product development.

## Safety Assessment

S-ethyl 2-acetylaminoethanethioate has not been evaluated for GRAS (Generally Recognized As Safe) status by the FDA, meaning it has not undergone the formal FDA GRAS notification process. However, this does not indicate safety concerns; rather, it reflects that either a formal safety petition has not been submitted or the compound has limited commercial use in the United States food supply.

According to available FDA records, there have been no reported adverse events associated with this additive and no product recalls linked to its presence. The absence of adverse event reports and recalls suggests no identified safety issues have been documented in the U.S. food safety surveillance system.

The limited publicly available toxicological data specific to this compound means that comprehensive safety assessments from independent scientific literature are not readily accessible. Safety evaluations for synthetic flavoring agents typically consider acute toxicity, potential genotoxicity, and potential effects on relevant biological systems based on chemical structure and metabolism. The structural presence of a thioester group warrants consideration of metabolic fate, as such moieties can be hydrolyzed by esterases in biological systems.

## Regulatory Status

In the United States, S-ethyl 2-acetylaminoethanethioate does not have FDA GRAS status. This means that if used as a food additive in the U.S., it would require either a food additive petition demonstrating safety or classification under another regulatory pathway. The absence of GRAS status does not necessarily reflect safety concerns but may indicate limited commercial demand, restricted use, or that safety documentation has not been formally submitted to the FDA.

Regulatory status in other jurisdictions, including the European Union, would depend on whether the compound appears on approved flavor ingredient lists in those regions. International flavor ingredient regulations vary, and compounds approved in one region may not be approved in others.

## Key Studies

Publicly available peer-reviewed toxicological studies specifically examining S-ethyl 2-acetylaminoethanethioate appear limited in the scientific literature. Comprehensive safety data for this specific compound would typically be found in proprietary safety submissions to regulatory agencies or in technical documentation held by flavor manufacturers.

For structurally related compounds and thioester-containing flavor molecules, toxicological principles established for synthetic flavoring agents generally apply, including assessment through the Flavor and Extract Manufacturers Association (FEMA) process or equivalent international procedures. Any safety assessment would consider the compound's chemical structure, predicted metabolism, intended use levels, and dietary exposure estimates.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "S-ethyl 2-acetylaminoethanethioate — Safety, regulation, and evidence." https://additivefacts.com/additives/s-ethyl-2-acetylaminoethanethioate. Accessed 2026-05-19.