# (+/-)-[r-(e)]-5-isopropyl-8-methylnona-6,8-dien-2-one

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**Safety rating:** UNKNOWN
**CAS number:** 2278-53-7
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

5-isopropyl-8-methylnona-6,8-dien-2-one (CAS 2278-53-7) is a synthetic organic compound used as a flavoring agent in food products. It functions as a flavor adjuvant to enhance or modify taste and aroma in various food applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is 5-isopropyl-8-methylnona-6,8-dien-2-one?

5-isopropyl-8-methylnona-6,8-dien-2-one, identified by CAS Number 2278-53-7, is a synthetic flavor compound belonging to the class of organic compounds known as ketones. The substance is characterized by its complex molecular structure containing isopropyl and methyl functional groups attached to a nine-carbon backbone with two double bonds (diene configuration). This structural composition contributes to its sensory properties and flavor profile.

## Common Uses

This flavoring agent is primarily employed in the food industry as a flavor component in various processed foods and beverages. Like other synthetic flavor compounds, it is used in small quantities to enhance or create specific taste and aroma characteristics. The compound may be incorporated into products such as confectionery, baked goods, beverages, dairy products, and other food categories where flavor enhancement is desired. The specific applications depend on the sensory characteristics the manufacturer aims to achieve.

## Safety Assessment

According to FDA records, there are no reported adverse events associated with this additive, and no food recalls have been linked to its use. This absence of reported incidents suggests a favorable safety profile in practical food applications at permitted usage levels. The substance has not been the subject of significant safety concerns in published scientific literature.

As with all food additives, safety depends on exposure levels and intended use. The FDA evaluates food additives based on their intended use conditions, including the level of consumption expected in the diet. Since this compound functions as a flavor adjuvant, it is used at relatively low concentrations, which minimizes dietary exposure.

## Regulatory Status

This additive is not listed as Generally Recognized as Safe (GRAS) by the FDA. This classification does not necessarily indicate a safety concern but rather reflects the regulatory pathway and available safety documentation. Many flavor compounds operate legally in food under specific FDA regulations or as constituents of flavor preparations that have undergone appropriate regulatory review.

The compound's regulatory status may vary by jurisdiction. Different regulatory bodies worldwide, including the European Food Safety Authority (EFSA), maintain separate evaluations and approvals for flavoring substances. Manufacturers must ensure compliance with regulations in all markets where products are distributed.

## Key Studies

Limited published scientific literature specifically addresses this particular synthetic flavor compound in peer-reviewed journals. The lack of published research may reflect both its narrow application in the food industry and the general safety record of similar synthetic flavor compounds in this chemical class.

For regulatory purposes, safety assessments of flavor compounds typically rely on structural activity relationships (SAR), data from chemically similar compounds, and toxicological testing where required. Flavor and Extract Manufacturers' Association (FEMA) and similar organizations often conduct or compile safety data for flavor ingredients used globally.

When evaluating flavoring agents, regulatory agencies consider factors including: proposed use levels, estimated dietary exposure, structural similarity to approved compounds, and any available toxicological data. The absence of adverse event reports and recalls provides practical evidence supporting the safe use of this additive under current food industry practices.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "(+/-)-[r-(e)]-5-isopropyl-8-methylnona-6,8-dien-2-one — Safety, regulation, and evidence." https://additivefacts.com/additives/r-e-5-isopropyl-8-methylnona-6-8-dien-2-one. Accessed 2026-05-19.