# Piperitenone Oxide

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**Safety rating:** UNKNOWN
**CAS number:** 35178-55-3
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Piperitenone oxide (CAS 35178-55-3) is an organic compound derived from natural sources used as a flavoring agent in food products. It functions as a flavor adjuvant to enhance or modify taste profiles in various food and beverage applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | approved |
| Canada | approved |
| Australia | approved |
| Japan | approved |
| South Korea | approved |
| Brazil | approved |
| China | approved |
| India | approved |

## Detailed analysis

## What is Piperitenone Oxide?

Piperitenone oxide is an organic chemical compound classified as a naturally-derived flavoring substance. It is a ketone derivative with the molecular formula C₁₁H₁₆O₂. The compound is structurally related to compounds found in peppermint and other aromatic plants. As a flavoring agent, it contributes to the sensory characteristics of food products by providing spice-like, herbal, or minty taste notes depending on application context.

## Common Uses

Piperitenone oxide is used primarily in the food and beverage industry as a flavoring agent and flavor adjuvant. Its applications include:

- Beverages (both alcoholic and non-alcoholic)
- Confectionery and candy products
- Savory snack foods
- Condiments and seasonings
- Baked goods and desserts

The compound is typically used in very small quantities—measured in parts per million (ppm)—to achieve desired flavor profiles without contributing significantly to the nutritional composition of foods.

## Safety Assessment

Piperitenone oxide has not been formally evaluated and approved by the FDA as a Generally Recognized as Safe (GRAS) substance for use in food. However, it has not been associated with any adverse events or recalls according to FDA records, indicating no documented safety incidents in reported food use.

The absence of a GRAS status does not necessarily indicate a safety concern; rather, it indicates that formal FDA evaluation and approval through the GRAS notification process has not been completed. Some flavoring compounds operate in commerce based on historical use or other regulatory pathways.

As with other naturally-derived flavoring compounds, piperitenone oxide would be expected to be used at levels well below any threshold of toxicological concern (TTC), which is a standard risk assessment approach for flavoring substances used at very low concentrations.

## Regulatory Status

In the United States, piperitenone oxide is not listed as an approved GRAS flavoring by the FDA. However, this does not mean it is prohibited for use. Manufacturers using this ingredient may do so under the assumption of prior sanction, historical use, or other legal frameworks that allow certain flavoring substances to be used in food without explicit GRAS approval.

The European Union's approach to flavoring substances typically includes piperitenone oxide in various regulatory categories for flavoring use, though specific approval status may vary by application.

Importers and manufacturers of products containing piperitenone oxide bear responsibility for ensuring compliance with applicable food safety regulations in their respective markets.

## Key Studies

Limited published scientific literature specifically addresses the toxicological profile of piperitenone oxide in isolation. The compound's safety assessment generally relies on:

1. **Structural relationship analysis**: Comparison with related compounds that have established safety profiles in food applications
2. **Usage levels**: The extremely low concentrations at which flavoring agents are used in food (typically less than 10 ppm)
3. **Historical use data**: Documentation of use in food products without reported adverse events
4. **Chemical class considerations**: Evaluation within the context of known safety data for similar ketone-based flavoring compounds

The Flavor and Extract Manufacturers Association (FEMA) maintains a database of flavoring substances and their safety evaluations, which may include assessment of compounds like piperitenone oxide based on available scientific evidence.

As with many naturally-derived flavoring compounds, comprehensive acute and chronic toxicity studies may not be publicly available, and safety determinations are often based on weight-of-evidence approaches rather than extensive published research on the individual compound.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Piperitenone Oxide — Safety, regulation, and evidence." https://additivefacts.com/additives/piperitenone-oxide. Accessed 2026-05-19.