# N-ethyl-2,2-diisopropylbutanamide

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**Safety rating:** UNKNOWN
**CAS number:** 51115-70-9
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

N-ethyl-2,2-diisopropylbutanamide (CAS 51115-70-9) is a synthetic organic compound used as a flavoring agent or flavoring adjuvant in food products. It belongs to the class of amide-based flavor compounds designed to enhance or modify taste profiles in processed foods.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is N-ethyl-2,2-diisopropylbutanamide?

N-ethyl-2,2-diisopropylbutanamide is a synthetic flavoring compound classified chemically as an amide derivative. Its CAS number 51115-70-9 uniquely identifies this substance in chemical databases and regulatory filings. The compound consists of a butanamide core structure with ethyl and diisopropyl substitutions, creating a complex organic molecule designed specifically for flavoring applications in the food industry.

## Common Uses

This additive functions as a flavoring agent or flavoring adjuvant in processed foods and beverages. Flavoring adjuvants are compounds that enhance, modify, or complement the sensory perception of taste and aroma in food products. They are typically used in very small quantities—measured in parts per million—to achieve desired flavor profiles. The specific organoleptic properties of N-ethyl-2,2-diisopropylbutanamide make it suitable for particular flavor applications in the food manufacturing sector, though detailed usage levels and specific food categories are proprietary information held by manufacturers.

## Safety Assessment

Available safety data for N-ethyl-2,2-diisopropylbutanamide indicates no reported adverse events or recalls associated with this substance in FDA databases. The compound has not generated safety concerns in post-market surveillance systems. However, it is important to note that this additive does not hold GRAS (Generally Recognized As Safe) status with the FDA, which means it has not undergone the formal GRAS determination process. The absence of GRAS status does not necessarily indicate safety concerns; rather, it reflects that the company or entity responsible for the additive has not submitted comprehensive safety data to the FDA for this particular determination.

The safety profile of synthetic flavoring compounds like this one depends on factors including chemical stability, metabolic fate in the body, potential for bioaccumulation, and any known toxicological properties. As an amide-based compound, it follows typical metabolic pathways for similar synthetic flavoring molecules. The low usage levels typical of flavoring agents in food—generally recognized as significantly below levels that would pose toxicological concern—contribute to the overall safety margin.

## Regulatory Status

N-ethyl-2,2-diisopropylbutanamide's regulatory status varies internationally. In the United States, while it does not hold GRAS approval, it may be permitted for use in certain food categories under FDA regulations if submitted under other approval pathways or if it qualifies under established exemptions. Manufacturers must ensure compliance with applicable regulations in each market where the additive is used. In the European Union and other regulatory jurisdictions, synthetic flavoring compounds are evaluated individually for safety and approval status. Regulatory bodies worldwide maintain ongoing monitoring of all food additives, including flavoring agents, for any emerging safety data.

## Key Studies

Limited published scientific literature specifically addressing N-ethyl-2,2-diisopropylbutanamide is available in the public domain, which is typical for proprietary synthetic flavoring compounds. Safety assessments of similar amide-based flavor compounds and general toxicological data for structurally related molecules inform understanding of this additive's likely safety profile. The lack of adverse event reports or recalls in FDA databases provides indirect evidence of safety during current use patterns, though this does not replace comprehensive pre-market safety testing.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "N-ethyl-2,2-diisopropylbutanamide — Safety, regulation, and evidence." https://additivefacts.com/additives/n-ethyl-2-2-diisopropylbutanamide. Accessed 2026-05-19.