# Monoammonium Glutamate (E624)

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**Safety rating:** UNKNOWN
**E-number:** E624
**CAS number:** 7558-63-6
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-04

## Summary

Monoammonium glutamate is a salt form of glutamic acid that functions as a flavor enhancer and stabilizer in food products. It is structurally related to monosodium glutamate (MSG) but contains ammonia instead of sodium, and is used to intensify savory flavors and improve product texture.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | approved |
| Canada | approved |
| Australia | approved |
| Japan | approved |
| South Korea | approved |
| Brazil | approved |
| China | approved |
| India | approved |

## Detailed analysis

## What is Monoammonium Glutamate?

Monoammonium glutamate (MAG) is the ammonium salt of L-glutamic acid, an amino acid naturally found in many foods. It has the chemical formula C5H10NO4·NH3 and CAS number 7558-63-6. Like monosodium glutamate (MSG), monoammonium glutamate dissociates in food systems to release free glutamate ions, which are responsible for umami taste perception—the savory sensation distinct from sweet, salty, sour, and bitter tastes.

## Common Uses

Monoammonium glutamate is primarily used in the food industry as a flavor enhancer in savory products including soups, broths, seasonings, processed meats, and snack foods. Its secondary function as a stabilizer or thickener makes it useful in formulations where texture modification is desired alongside flavor enhancement. The ammonia component differentiates it from sodium-based glutamates, potentially offering alternative formulation options for products where sodium reduction is a goal, though this remains a niche application.

## Safety Assessment

The safety profile of monoammonium glutamate remains limited in the scientific literature compared to MSG, which has been extensively studied. According to FDA records, there have been zero reported adverse events specifically attributed to monoammonium glutamate and zero recalls linked to this ingredient, suggesting a favorable safety record in commercial use. However, the lack of widespread use and limited independent research means safety data is less comprehensive than for more common glutamates.

As a salt of glutamic acid, monoammonium glutamate would be expected to behave similarly to other glutamate salts in the body following consumption. Glutamate is a naturally occurring amino acid and neurotransmitter that plays a normal role in human metabolism. The ammonia component is also naturally produced and metabolized in the body. However, formal toxicological studies specifically evaluating monoammonium glutamate have not been published in major peer-reviewed journals, leaving some gaps in the scientific evidence base.

## Regulatory Status

Monoammonium glutamate is not listed as Generally Recognized as Safe (GRAS) by the FDA, distinguishing it from MSG and some other glutamates that have GRAS status. This does not necessarily indicate safety concerns; rather, it reflects that GRAS affirmation or determination has not been sought or obtained for this particular ingredient through FDA's formal processes. The ingredient may be used in foods under FDA regulations for food additives, subject to established limitations. It is not prohibited or banned in any major food regulatory jurisdiction based on available information. Regulatory status may vary internationally, with different approvals in the European Union, Canada, and other regions.

## Key Studies

Direct published research on monoammonium glutamate is sparse. Most relevant safety information derives from studies on glutamate salts generally and monosodium glutamate specifically, given the shared glutamate moiety. A 2000 review in the Journal of Nutrition examined the safety of MSG and concluded that for the general population, typical dietary consumption levels were not associated with adverse effects. However, this research focused on sodium-based glutamate rather than the ammonia variant.

The metabolism and toxicology of ammonia salts is well-characterized from other compounds, and ammonia in dietary amounts is safely processed by normal liver metabolism. Additional research directly comparing monoammonium glutamate to other glutamate salts would strengthen the evidence base for this specific ingredient.

Consumers with concerns about ammonia-containing compounds or unusual sensitivities to amino acids may wish to consult available product ingredient lists and speak with healthcare providers if they have specific dietary restrictions.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Monoammonium Glutamate (E624) — Safety, regulation, and evidence." https://additivefacts.com/additives/monoammonium-glutamate. Accessed 2026-05-20.