# Methylthio 2-(propionyloxy)propionate

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**Safety rating:** UNKNOWN
**CAS number:** 977161-96-8
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Methylthio 2-(propionyloxy)propionate is a synthetic flavoring compound used to impart specific taste and aroma characteristics in food products. This substance functions as a flavoring agent or adjuvant in the food industry, though it has not received FDA GRAS (Generally Recognized as Safe) status.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Methylthio 2-(propionyloxy)propionate?

Methylthio 2-(propionyloxy)propionate, identified by CAS Number 977161-96-8, is a synthetic organic compound belonging to the flavoring agents category. It is a complex ester containing both methylthio and propionyloxy functional groups. This chemical structure allows it to contribute specific aromatic and taste properties to food formulations. As a flavoring agent or adjuvant, it is designed to enhance or modify the sensory profile of food and beverage products.

## Common Uses

This flavoring compound is utilized in the food industry primarily as a flavoring agent or taste modifier. Like other synthetic flavoring substances, it would typically be incorporated into processed food products at very low concentrations to achieve desired flavor profiles. The specific aromatic characteristics imparted by this compound make it suitable for particular food applications, though detailed commercial usage information remains limited in public databases. Flavoring agents of this type are generally used in products where precise sensory control is important to manufacturers.

## Safety Assessment

According to available FDA records, there have been zero reported adverse events associated with this additive and zero recalls related to its use. These figures suggest no documented safety incidents have been formally reported to the FDA. However, it is important to note that the absence of reported incidents does not necessarily indicate comprehensive long-term safety data. The compound has not received FDA GRAS status, which means it has not undergone the formal FDA review process to be classified as Generally Recognized as Safe by qualified experts.

Limited published scientific literature is currently available regarding the toxicological profile of this specific compound. As with many synthetic flavoring agents, safety would typically depend on factors including: intended use levels, frequency of exposure, the target population consuming products containing it, and cumulative dietary exposure from all sources.

## Regulatory Status

This additive does not hold FDA GRAS status, distinguishing it from many other flavoring compounds that have undergone formal safety review. In the United States, food additives not on the GRAS list typically require FDA approval through the food additive petition process before use in food. The regulatory status in other jurisdictions, including Europe and other countries, may differ. Manufacturers considering use of this substance in food products would need to verify compliance with applicable regulations in their target markets.

## Key Studies

Publicly available peer-reviewed studies specifically evaluating the safety or efficacy of methylthio 2-(propionyloxy)propionate appear limited in scientific literature databases. The compound's relatively recent CAS number assignment (977161-96-8) suggests it may be a more recently developed or characterized substance. Further research and toxicological evaluation may be necessary to establish comprehensive safety and use data. Interested parties should consult the FDA's Food Additive Status List and contact relevant regulatory agencies for the most current information regarding this substance's regulatory standing and any pending safety assessments.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Methylthio 2-(propionyloxy)propionate — Safety, regulation, and evidence." https://additivefacts.com/additives/methylthio-2-propionyloxy-propionate. Accessed 2026-05-19.