# Methyl Phenethyl Ether

> Source URL: https://additivefacts.com/additives/methyl-phenethyl-ether
> Markdown URL: https://additivefacts.com/additives/methyl-phenethyl-ether.md

**Safety rating:** UNKNOWN
**CAS number:** 3558-60-9
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Methyl phenethyl ether is an organic flavoring compound used to impart specific aromatic characteristics to food products. This synthetic flavoring agent is not currently approved as GRAS (Generally Recognized as Safe) by the FDA but has been used in limited food applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Methyl Phenethyl Ether?

Methyl phenethyl ether (CAS Number 3558-60-9) is an organic chemical compound belonging to the class of phenethyl ether derivatives. It is a synthetic flavoring agent characterized by a molecular structure consisting of a phenethyl group bonded to a methyl ether functional group. This compound is volatile and contributes aromatic properties to food formulations.

## Common Uses

Methyl phenethyl ether is primarily used in the food industry as a flavoring agent or flavoring adjuvant. It is incorporated into food products to provide or enhance specific flavor notes and aromatic characteristics. The compound is typically used in small quantities due to its potency as a flavoring ingredient. Like other synthetic flavor compounds, it may appear in beverages, confectionery products, baked goods, and other processed foods where specific flavor profiles are desired.

## Safety Assessment

The safety profile of methyl phenethyl ether is characterized by limited but notable data. According to FDA records, there have been zero reported adverse events associated with this additive, and no product recalls have been issued related to its use. However, it is important to note that the absence of reported adverse events does not constitute formal safety approval. The compound is not on the FDA's GRAS (Generally Recognized as Safe) list, which means it has not undergone the formal review process that would grant it GRAS status in the United States.

The lack of GRAS designation suggests that comprehensive safety data may be limited or that the compound has not been formally submitted for GRAS evaluation. Food manufacturers using this ingredient in the United States would need to comply with applicable regulations regarding food additives and may require specific approval depending on intended use levels and food categories.

## Regulatory Status

In the United States, methyl phenethyl ether operates under a different regulatory framework than GRAS-approved additives. Without GRAS status, its use may be subject to specific regulatory requirements and limitations. The FDA maintains oversight of flavoring agents used in food, and manufacturers must ensure compliance with food additive regulations (21 CFR Part 570).

Regulatory status may vary internationally. Other regulatory bodies, such as the European Food Safety Authority (EFSA), maintain separate review processes and approval lists for flavoring compounds. Manufacturers seeking to use this ingredient in international markets should verify compliance with local food safety regulations in each jurisdiction.

## Key Studies

Limited published literature is available specifically addressing the safety and toxicology of methyl phenethyl ether. Most data on phenethyl ether derivatives comes from structural class evaluations conducted by flavor and fragrance industry organizations and regulatory bodies. These evaluations typically consider the chemical structure, intended use levels, and metabolism patterns of related compounds.

The compound's chemical classification as a phenethyl ether places it within a broader category of compounds that have been evaluated for general safety characteristics. However, specific toxicological studies or ADME (absorption, distribution, metabolism, excretion) data specifically focused on methyl phenethyl ether appear limited in the public literature.

Flavor industry organizations maintain databases of flavoring compounds and their safety assessments. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) and the Flavor and Extract Manufacturers' Association (FEMA) provide frameworks for evaluating flavor compound safety, though methyl phenethyl ether's inclusion in such evaluations would require verification through direct sources.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Methyl Phenethyl Ether — Safety, regulation, and evidence." https://additivefacts.com/additives/methyl-phenethyl-ether. Accessed 2026-05-19.