# Methyl N,n-dimethylanthranilate

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**Safety rating:** UNKNOWN
**CAS number:** 10072-05-6
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Methyl N,n-dimethylanthranilate (CAS 10072-05-6) is a synthetic flavoring agent used to impart grape and berry flavors in food and beverages. It is not currently approved as Generally Recognized as Safe (GRAS) by the FDA in the United States.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Methyl N,n-dimethylanthranilate?

Methyl N,n-dimethylanthranilate is a synthetic organic compound belonging to the class of aromatic esters used as flavoring agents in the food industry. Its chemical structure is derived from anthranilic acid, and it is characterized by its ability to produce grape and berry-like flavor notes. The compound is identified by CAS number 10072-05-6 and is utilized primarily in formulations requiring fruity flavor profiles.

## Common Uses

This flavoring agent is employed in various food and beverage applications where grape or berry flavor enhancement is desired. Potential uses include:

- Soft drinks and carbonated beverages
- Flavored beverages and juice drinks
- Confectionery and candy products
- Baked goods and desserts
- Dairy products and yogurts
- Frozen desserts and ice cream
- Flavored syrups and concentrates

The compound's organoleptic properties make it valuable for manufacturers seeking to create or enhance fruity taste profiles in consumer products.

## Safety Assessment

Methyl N,n-dimethylanthranilate has not generated any documented adverse events according to FDA records, and no recalls associated with this ingredient have been reported in the United States. This suggests a favorable safety profile based on available post-market surveillance data.

As with all synthetic flavoring agents, safety assessment has primarily been based on:

- Chemical structure and metabolism studies
- Toxicological evaluation data
- Existing regulatory frameworks in other jurisdictions
- Acceptable daily intake (ADI) determinations where established

The absence of reported adverse events does not constitute FDA approval as a GRAS substance in the United States. GRAS designation requires either substantial scientific consensus or a successful FDA petition demonstrating safe use at intended levels.

## Regulatory Status

In the United States, methyl N,n-dimethylanthranilate is not listed as GRAS by the FDA. This means:

- It cannot be used in food products without specific FDA authorization
- Food manufacturers wishing to use this ingredient would typically need to submit a food additive petition to the FDA
- The ingredient may be approved for use in other countries under different regulatory frameworks

Regulatory approval varies internationally. Some countries may permit this flavoring under their respective food additive regulations, while others may maintain different approval statuses. Manufacturers must comply with regulations in each market where products are intended for sale.

The European Union, through EFSA (European Food Safety Authority), maintains separate authorization lists for food additives and flavoring substances. Approval status in the EU may differ from U.S. regulatory determinations.

## Key Studies

Limited published literature is available specifically evaluating methyl N,n-dimethylanthranilate at the consumer exposure levels used in food applications. Safety information typically derives from:

- Structural analogue studies with related anthranilic acid derivatives
- General toxicological screening for synthetic flavoring compounds
- Metabolism and pharmacokinetic data for similar aromatic compounds
- International regulatory assessments by food safety authorities

The flavoring industry and regulatory bodies often utilize Flavor and Extract Manufacturers' Association (FEMA) GRAS determinations as guidance, though this compound's specific status would require verification through current regulatory databases.

Researchers and manufacturers continue to contribute to the safety database for approved and candidate flavoring substances through submission of technical dossiers to regulatory authorities.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Methyl N,n-dimethylanthranilate — Safety, regulation, and evidence." https://additivefacts.com/additives/methyl-n-n-dimethylanthranilate. Accessed 2026-05-19.