# Methyl 2-octynoate

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**Safety rating:** SAFE
**CAS number:** 111-12-6
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Methyl 2-octynoate (CAS 111-12-6) is a synthetic flavoring compound used to impart fruity and herbaceous notes in food and beverage products. It functions as a flavoring agent to enhance or create desired taste profiles in processed foods.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | approved |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Methyl 2-octynoate?

Methyl 2-octynoate is a synthetic organic compound classified as a flavoring agent. Structurally, it is a methyl ester with an alkyne functional group at the second position of an eight-carbon chain. This compound is manufactured through chemical synthesis rather than derived from natural sources, though similar aromatic compounds exist in nature. It appears as a colorless to pale yellow liquid with a fruity, slightly herbaceous odor profile.

## Common Uses

Methyl 2-octynoate is used primarily in the flavor industry as a component in compound flavorings for processed foods and beverages. Its applications include:

- Fruit-flavored beverages and soft drinks
- Confectionery and candy products
- Baked goods and desserts
- Dairy products including yogurts and flavored milk
- Savory snack seasonings

The compound contributes fruity and slightly floral notes that complement other flavor components in formulations. It is typically used at very low concentrations, measured in parts per million (ppm), to achieve the desired sensory effect without overwhelming other flavor notes.

## Safety Assessment

Methyl 2-octynoate has not been formally evaluated by the FDA as a Generally Recognized As Safe (GRAS) substance through the official GRAS notification process. However, the absence of an FDA GRAS determination does not indicate unsafe status. Rather, it reflects that the compound may be used under food additive regulations through other pathways, or that formal GRAS notification has not been pursued.

The compound has generated zero adverse event reports in the FDA adverse event database and has been associated with zero FDA recalls. This absence of reported safety incidents, combined with its long history of use in flavoring applications without documented harm, suggests an acceptable safety profile at levels of use in food.

Methyl 2-octynoate is structurally similar to other approved flavoring compounds and undergoes typical metabolic pathways. At the extremely low concentrations used in flavored foods (typically less than 10 ppm), systemic exposure is minimal. The alkyne functional group does not raise specific toxicological concerns at these usage levels.

## Regulatory Status

In the United States, methyl 2-octynoate is permitted for use as a flavoring agent under FDA regulations (21 CFR § 182.60) as a synthetic flavoring substance. While not formally GRAS-listed, it is considered acceptable for use in food at levels that accomplish the intended flavoring effect.

The European Food Safety Authority (EFSA) has included similar aliphatic unsaturated alcohols and esters in their evaluations of flavoring substances. Methyl 2-octynoate falls within categories of compounds generally recognized as acceptable in the European Union's flavor regulations.

This compound is not restricted or banned in major food-producing regions, and its use continues in commercial flavoring formulations globally.

## Key Studies

Primary safety information comes from:

- Industry toxicology data submitted to regulatory agencies
- General studies on synthetic flavoring compounds with similar chemical structures
- Metabolism and safety evaluations of alkyne-containing esters
- Extensive use history in commercial flavoring applications without adverse reports

The lack of negative safety data, combined with appropriate use levels in food applications, supports continued use as a flavoring component. However, formal chronic toxicity studies specific to this compound are limited in published literature, which is typical for minor flavoring ingredients used at extremely low concentrations.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Methyl 2-octynoate — Safety, regulation, and evidence." https://additivefacts.com/additives/methyl-2-octynoate. Accessed 2026-05-19.