# Isopropyl-2-cyclohexenone

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**Safety rating:** UNKNOWN
**CAS number:** 500-02-7
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Isopropyl-2-cyclohexenone is a synthetic organic compound used as a flavoring agent in food products. It imparts a spicy, woody, or herbaceous taste profile and is employed in small quantities to enhance flavor complexity in various food applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Isopropyl-2-cyclohexenone?

Isopropyl-2-cyclohexenone (CAS Number 500-02-7) is a synthetic flavoring compound belonging to the class of organic molecules known as cyclohexenones. It is a colorless to pale yellow liquid with a characteristic spicy and woody aroma. The compound consists of a six-membered carbon ring with one double bond, substituted with an isopropyl group. As a synthetic flavoring agent, it does not occur naturally in significant quantities and is manufactured through chemical synthesis for use in food applications.

## Common Uses

Isopropyl-2-cyclohexenone is utilized primarily as a flavoring agent or flavoring adjuvant in the food industry. It is typically employed in very small concentrations to provide or enhance spicy, woody, herbal, or slightly peppery taste notes in various food and beverage products. Common applications may include seasonings, spice blends, savory snacks, condiments, and flavored beverages. Like most synthetic flavoring compounds, it functions as a taste modifier rather than a primary ingredient, allowing formulators to achieve desired flavor profiles with precision and consistency.

## Safety Assessment

The safety profile of isopropyl-2-cyclohexenone appears limited in terms of extensive published data. The FDA has received zero adverse events reports associated with this additive, and there have been no FDA recalls involving this substance. However, it is important to note that this compound does not hold FDA GRAS (Generally Recognized As Safe) status, which means it has not undergone the formal determination process that many other flavoring agents have completed.

The absence of reported adverse events and recalls suggests that any exposure through food consumption has not resulted in identified safety concerns at typical use levels. Synthetic flavoring agents in this chemical class are generally recognized to be used at levels well below thresholds of toxicological concern, following international flavor safety assessment frameworks. The European Food Safety Authority (EFSA) and the International Organization of the Flavoring Industry (IOFI) have established safety evaluation procedures for such compounds based on their chemical structure and intended use levels.

## Regulatory Status

Isopropyl-2-cyclohexenone operates in a regulatory gray area in some jurisdictions. While it is not explicitly banned in the United States, it does not hold FDA GRAS status, meaning it may be used as a food additive under the FDA's indirect food additive regulations or as part of flavor mixtures, but it has not completed formal GRAS affirmation. In the European Union, the regulatory status depends on whether it appears on the approved flavoring substances list, and approval may vary by member state.

Manufacturers using this compound must ensure compliance with their relevant regulatory frameworks and typically maintain usage levels consistent with established safety guidelines for synthetic flavoring agents. The lack of GRAS designation does not necessarily indicate a safety concern but rather reflects the extent of formal regulatory review the compound has undergone.

## Key Studies

Limited published scientific literature specifically addresses isopropyl-2-cyclohexenone in peer-reviewed studies. The compound has not been the subject of major toxicological investigations published in widely accessible databases. Safety assessments for synthetic flavoring agents of similar chemical structure and intended use levels typically follow structure-activity relationship (SAR) approaches and threshold of toxicological concern (TTC) methodologies established by international expert bodies.

The absence of adverse event reports and regulatory recalls, combined with its use at minimal concentrations in food applications, suggests practical safety at intended exposure levels. However, comprehensive toxicological data specific to this individual compound appears limited in the public domain. Interested parties may reference safety assessments compiled by the Flavor and Extract Manufacturers Association (FEMA) or contact manufacturers directly for detailed safety documentation prepared during product development.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Isopropyl-2-cyclohexenone — Safety, regulation, and evidence." https://additivefacts.com/additives/isopropyl-2-cyclohexenone. Accessed 2026-05-19.