# Isopropenylpyrazine

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**Safety rating:** UNKNOWN
**CAS number:** 38713-41-6
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Isopropenylpyrazine (CAS 38713-41-6) is an organic compound used as a flavoring agent in food products. It belongs to the pyrazine family of flavor compounds and is employed to impart specific aromatic characteristics to various food and beverage applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Isopropenylpyrazine?

Isopropenylpyrazine is a synthetic organic compound classified as a flavoring agent or flavoring adjuvant. It is a member of the pyrazine family, a group of nitrogen-containing aromatic compounds known for their distinctive sensory properties. The compound has the CAS registry number 38713-41-6, which uniquely identifies it in chemical databases. Isopropenylpyrazine exists as a colorless to pale yellow liquid and is used in minute quantities in food formulations to enhance or modify flavor profiles.

## Common Uses

Isopropenylpyrazine is utilized as a flavoring ingredient in the food and beverage industry. Like other pyrazine-based compounds, it contributes nutty, roasted, or earthy flavor notes that are valued in various food applications. The compound is used at very low concentrations, typically in the parts per million range, to achieve desired sensory effects. It may be incorporated into products such as baked goods, beverages, confections, and other processed foods where flavor enhancement is desired. The specific applications depend on formulation requirements and regional regulatory approvals.

## Safety Assessment

According to FDA records, there have been no adverse events reported in connection with isopropenylpyrazine, and no product recalls involving this ingredient have been documented. The compound has not been designated as Generally Recognized as Safe (GRAS) by the FDA, which means it does not benefit from the streamlined approval pathway available to GRAS substances. However, the absence of GRAS status does not indicate a safety concern; rather, it reflects the regulatory pathway through which the ingredient is approved for use.

The toxicological profile of isopropenylpyrazine has not been extensively documented in publicly available scientific literature. Like other flavoring agents used in food, the safety assessment typically relies on data regarding its intended use levels, chemical stability, and metabolism. Flavoring agents are generally used at extremely low concentrations, which limits dietary exposure. The lack of reported adverse events and recalls suggests that the compound has been used without documented safety incidents in food applications where it has been approved.

## Regulatory Status

Isopropenylpyrazine is not approved as a GRAS ingredient in the United States. Its regulatory status varies by jurisdiction. In the European Union, approval and safety assessment of flavoring agents are conducted through the European Food Safety Authority (EFSA), which maintains detailed regulations on approved flavorings. The specific regulatory pathway and approval status of isopropenylpyrazine should be verified with relevant regulatory authorities in the country or region where it is intended for use.

Manufacturers utilizing isopropenylpyrazine in food products must comply with applicable regulations in their target markets. In the United States, flavoring ingredients may be approved through the FDA's Food Additive Petition process, where manufacturers submit safety data for evaluation. Regulatory approval ensures that only approved ingredients at approved use levels are incorporated into food products.

## Key Studies

Publicly available scientific literature specifically addressing isopropenylpyrazine is limited. Safety assessments for flavor compounds typically follow established toxicological testing protocols, including acute toxicity studies, repeated-dose studies, and genotoxicity assessments. The extent of available safety data for this specific compound should be verified through regulatory agencies and manufacturers.

General knowledge regarding pyrazine compounds suggests they are metabolized and eliminated relatively rapidly from the body. The use of such compounds at minimal concentrations in food represents low dietary exposure. Continued monitoring through adverse event reporting systems, such as the FDA's adverse event database, provides ongoing safety surveillance for approved food ingredients.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Isopropenylpyrazine — Safety, regulation, and evidence." https://additivefacts.com/additives/isopropenylpyrazine. Accessed 2026-05-19.