# Isoeugenyl Methyl Ether

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**Safety rating:** SAFE
**CAS number:** 93-16-3
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Isoeugenyl methyl ether (CAS 93-16-3) is an organic compound derived from eugenol that functions as a flavoring agent in food products. It imparts a spicy, clove-like aroma and taste characteristic similar to its parent compound, making it useful in beverage and food flavoring applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Isoeugenyl Methyl Ether?

Isoeugenyl methyl ether is an aromatic organic compound with the chemical formula C11H14O2. It is a methylated derivative of isoeugenol, which itself is an isomer of eugenol—a naturally occurring compound found in clove oil and other botanical sources. The compound appears as a colorless to pale yellow liquid with a characteristic spicy, clove-like odor. Due to its sensory properties, it has been utilized in the flavor industry to create or enhance spice-forward taste profiles in various food and beverage products.

## Common Uses

Isoeugenyl methyl ether is employed as a flavoring agent and flavor adjuvant in the food industry. Its primary applications include:

- Beverage flavoring (alcoholic and non-alcoholic beverages)
- Spice-based food products and seasonings
- Confectionery and dessert flavors
- Savory food applications requiring clove or spice notes

The compound is valued for its ability to deliver authentic spice character at relatively low usage levels, making it cost-effective for manufacturers. As with other synthetic flavor compounds, it allows for consistent flavor delivery across product batches compared to variable natural extracts.

## Safety Assessment

Isoeugenyl methyl ether has generated no reported adverse events to the FDA and has not been associated with any FDA product recalls. This record suggests a low incidence of consumer complaints or safety issues related to its use in food applications.

Toxicological data on isoeugenyl methyl ether is limited in the published scientific literature. However, as a eugenol-derived compound, some safety parallels may be drawn. Eugenol itself has been extensively studied and is generally recognized as safe by regulatory agencies for use in food products at typical levels. The addition of a methyl ether group to create isoeugenyl methyl ether modifies the compound's properties, and compounds with similar structural features have typically shown low acute toxicity in standard testing protocols.

The compound has not been formally evaluated for GRAS (Generally Recognized As Safe) status by the FDA, meaning it does not currently have this official designation. This does not necessarily indicate a safety concern but rather reflects that a formal GRAS petition or notification may not have been submitted to the agency.

## Regulatory Status

Isoeugenyl methyl ether is not GRAS-affirmed by the FDA. However, the absence of recalls, adverse events, and the compound's use history suggest it has been employed in foods with a reasonable safety record. In the European Union, flavor compounds are subject to evaluation by the EFSA (European Food Safety Authority). The regulatory classification and approval status may vary between jurisdictions, and manufacturers using this ingredient should verify compliance with local regulations in their target markets.

The Food and Drug Administration maintains that color additives and certain other substances require pre-market approval, while flavor compounds have historically operated under different regulatory pathways. Manufacturers are responsible for ensuring ingredient safety and proper labeling.

## Key Studies

Published scientific literature specifically examining isoeugenyl methyl ether is limited. Most safety information for eugenol-related compounds comes from broader flavor chemical safety assessments. The flavor industry relies on structural activity relationship (SAR) modeling and historical use data for compounds in this chemical family. Regulatory decisions are typically informed by:

- Acute and subchronic toxicity studies
- Genotoxicity assessments
- Metabolic fate studies
- Historical use patterns and consumption data

Where formal safety studies on isoeugenyl methyl ether specifically have been conducted, they have generally supported its safe use at levels typical for flavor applications in food. Researchers and regulatory bodies continue to monitor emerging scientific literature on flavor compounds, and any new safety information would be evaluated by appropriate regulatory agencies.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Isoeugenyl Methyl Ether — Safety, regulation, and evidence." https://additivefacts.com/additives/isoeugenyl-methyl-ether. Accessed 2026-05-19.