# Hydroquinone Monoethyl Ether

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**Safety rating:** UNKNOWN
**CAS number:** 622-62-8
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Hydroquinone monoethyl ether (CAS 622-62-8) is an organic compound used as a flavoring agent and flavor enhancer in food products. It is not currently approved as Generally Recognized as Safe (GRAS) by the FDA, though no adverse events or recalls have been associated with it.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Hydroquinone Monoethyl Ether?

Hydroquinone monoethyl ether is a synthetic organic compound derived from hydroquinone, a benzene derivative. The compound consists of hydroquinone with one hydroxyl group substituted by an ethyl ether group. It exists as a white to off-white crystalline solid at room temperature. The chemical has the molecular formula C8H10O3 and is identified by CAS Number 622-62-8. Due to its aromatic nature and chemical structure, it can impart flavor characteristics to food products.

## Common Uses

Hydroquinone monoethyl ether is utilized in the food industry as a flavoring agent and flavor enhancer. Its primary function is to contribute or modify flavor profiles in processed foods, beverages, and food additives. Like other synthetic flavor compounds, it would typically be used in very small concentrations to achieve the desired sensory effect. The compound falls within the broader category of synthetic flavoring substances that manufacturers employ to enhance taste and aroma characteristics of food products. However, due to its non-GRAS status, it remains restricted in certain jurisdictions and its use is not universally permitted.

## Safety Assessment

According to FDA records, there have been zero adverse events and zero recalls associated with hydroquinone monoethyl ether. This absence of reported safety incidents suggests either limited use in the food supply or good safety margins when used in intended applications. However, the lack of reported adverse events does not automatically indicate comprehensive safety data availability. The compound has not been granted GRAS status by the FDA, which means it has not undergone the standard process of safety evaluation and approval for general use in food. GRAS status requires either substantial scientific agreement among qualified experts or the submission of a petition demonstrating safety based on published scientific evidence.

The compound's chemical relationship to hydroquinone—a substance with known toxicological properties—warrants consideration. Hydroquinone itself is regulated as a drug and skin-bleaching agent and is subject to specific restrictions. However, the ethyl ether modification significantly alters the chemical and toxicological properties of the parent compound. Without specific toxicological studies on the monoethyl ether form, definitive safety conclusions cannot be drawn solely from knowledge of hydroquinone.

## Regulatory Status

Hydroquinone monoethyl ether does not hold GRAS designation in the United States, meaning it cannot be legally added to food without FDA approval through a food additive petition. This regulatory status reflects the absence of a formal safety determination by the FDA. The compound may be approved or permitted under different regulatory frameworks in other countries, as individual nations maintain their own food additive approval systems. In the European Union, such compounds would require evaluation by the European Food Safety Authority (EFSA) before authorization. Manufacturers seeking to use this flavoring substance in regulated markets must comply with the specific requirements of each jurisdiction where their products are sold.

## Key Studies

Published scientific literature specifically evaluating the safety or efficacy of hydroquinone monoethyl ether in food applications appears limited. Most food safety databases and regulatory submissions focus on compounds with established GRAS or approved additive status. The lack of prominent studies in peer-reviewed literature may reflect the compound's limited commercial use or recent development. Any manufacturer considering use of this compound should consult current scientific literature and consider commissioning appropriate toxicological studies to support regulatory approval in target markets. The absence of reported adverse events or recalls provides limited insight without corresponding safety data from controlled studies.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Hydroquinone Monoethyl Ether — Safety, regulation, and evidence." https://additivefacts.com/additives/hydroquinone-monoethyl-ether. Accessed 2026-05-12.