# Hexyl Propionate

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**Safety rating:** SAFE
**CAS number:** 2445-76-3
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Hexyl propionate (CAS 2445-76-3) is a synthetic ester flavoring compound used to impart fruity, apple-like, and tropical fruit notes in food and beverage products. It functions as a flavoring agent to enhance or modify the sensory profile of processed foods.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Hexyl Propionate?

Hexyl propionate is a synthetic organic compound classified as an ester, formed from the combination of hexanol and propionic acid. It appears as a colorless to pale yellow liquid with a fruity aroma characteristic of apples, pears, and tropical fruits. The compound is identified by CAS number 2445-76-3 and is manufactured through chemical synthesis rather than extracted from natural sources, though chemically identical esters occur in some fruits.

## Common Uses

Hexyl propionate is primarily employed in the flavor industry as a flavoring agent and flavor adjuvant. It is used in small concentrations in a variety of processed food and beverage applications, including:

- Confectionery and candy products
- Baked goods and bakery items
- Beverages (both alcoholic and non-alcoholic)
- Dairy products and ice cream
- Flavored sauces and condiments
- Snack foods

The compound is valued for its ability to contribute fruity and fresh notes that appeal to consumer preferences for natural-tasting flavors, despite being synthetically produced.

## Safety Assessment

Hexyl propionate has not been formally evaluated or granted GRAS (Generally Recognized as Safe) status by the FDA. However, the absence of FDA GRAS designation does not indicate a safety concern. The additive can be legally used in foods under FDA regulations for color additives and other food ingredients when used in accordance with applicable guidelines.

As of the current data available, the FDA has recorded zero adverse events associated with hexyl propionate and zero recalls related to its use. This absence of reported safety issues suggests the compound has not generated consumer health complaints or regulatory actions based on safety concerns at typical usage levels.

The safety profile of hexyl propionate is generally supported by its chemical structure. Esters of this type are metabolized by the body through standard enzymatic pathways, breaking down into their constituent alcohols and acids, which are further metabolized through normal biochemical routes. The hexanol component and propionic acid are naturally occurring compounds found in foods and the human body.

## Regulatory Status

In the United States, hexyl propionate is permitted for use as a flavoring substance under 21 CFR 182.60, which covers synthetic flavoring substances and adjuvants. The compound is not banned by any major food regulatory authority.

The European Union's EFSA (European Food Safety Authority) has evaluated various ester-based flavorings, though specific data on hexyl propionate may be limited in publicly available assessments. Like many synthetic flavorings, it is permitted for use in the EU under Regulation (EC) No 1334/2008 on flavorings.

Usage levels in food applications are typically very small, measured in parts per million (ppm), reflecting the potent flavor impact of such compounds. This low-level use further reduces potential exposure concerns.

## Key Studies

Specific toxicological studies exclusively focused on hexyl propionate are limited in publicly available literature. However, the safety assessment of structurally similar ester flavorings has been conducted by flavor safety organizations, including the International Organization of the Flavor Industry (IOFI) and academic researchers.

General toxicological data on ester flavorings of similar molecular weight and structure indicate minimal acute toxicity and no significant chronic health effects at typical dietary exposure levels. The metabolic pathways for hexanol and propionic acid are well-established in human biochemistry.

The absence of adverse events or recalls provides practical evidence of safety during decades of commercial use in food products.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Hexyl Propionate — Safety, regulation, and evidence." https://additivefacts.com/additives/hexyl-propionate. Accessed 2026-05-19.