# Gamma-heptalactone

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> Markdown URL: https://additivefacts.com/additives/gamma-heptalactone.md

**Safety rating:** SAFE
**CAS number:** 105-21-5
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Gamma-heptalactone is a naturally occurring organic compound used as a flavoring agent in food products. It imparts a coconut, fruity, or creamy taste and odor to various food and beverage applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | approved |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Gamma-heptalactone?

Gamma-heptalactone (CAS Number: 105-21-5) is a lactone—a type of organic compound formed by the cyclization of hydroxy acids. It is a naturally occurring substance found in small quantities in certain fruits and other foods. The compound is colorless to pale yellow and has a distinctive coconut, fruity, or creamy aroma with sweet, buttery undertones. In food manufacturing, it is used in its synthetic form to replicate and enhance these natural flavors.

## Common Uses

Gamma-heptalactone functions as a flavoring agent and flavor adjuvant in the food industry. It is commonly employed in:

- Beverages (soft drinks, juices, dairy drinks)
- Dairy products (yogurts, ice cream, flavored milk)
- Confectionery and candy
- Baked goods and bakery products
- Flavor compounds and fragrance applications
- Processed foods requiring coconut or fruity notes

The compound is typically used in very small quantities, measured in parts per million (ppm), to achieve desired sensory characteristics without overwhelming the product's flavor profile.

## Safety Assessment

Gamma-heptalactone has been used in food flavoring applications with an established safety record. According to FDA records, there have been zero reported adverse events associated with this additive and zero product recalls attributed to gamma-heptalactone. This absence of reported safety incidents, combined with its natural occurrence in foods, suggests a favorable safety profile in food applications.

The compound undergoes metabolic breakdown in the human body through standard detoxification pathways. Like other lactones, it is processed through hydrolysis and conjugation reactions, ultimately resulting in elimination through normal physiological processes. The low concentrations at which it is used in food products further minimize potential exposure concerns.

Toxicological studies on similar lactone compounds and structurally related flavoring agents have not identified significant hazards at food-use levels. The compound does not appear to bioaccumulate in tissues and is not expected to pose systemic health risks when used within established food flavoring guidelines.

## Regulatory Status

Gamma-heptalactone is not currently listed on the FDA's Generally Recognized As Safe (GRAS) list. However, this designation does not indicate a safety concern; rather, it reflects that formal GRAS notification or petition processes have not been completed for this particular substance. The absence of GRAS status means its use in food products in the United States may be limited or require specific regulatory clearance depending on the food category and application.

In the European Union, gamma-heptalactone is recognized as a flavoring substance and is listed in the EU Register of Flavoring Substances used in or on foodstuffs. This listing permits its use within established parameters for flavor applications across EU member states.

Globally, regulatory acceptance varies by jurisdiction, with many countries permitting its use in flavor formulations under their respective food additive regulations. Manufacturers typically employ this ingredient at levels consistent with international flavoring industry standards.

## Key Studies

Research on gamma-heptalactone and structurally similar lactone compounds demonstrates good safety margins. Studies examining lactone metabolism indicate rapid and efficient clearance from the body without accumulation. Sensory evaluation studies confirm the compound's effectiveness as a flavoring agent at extremely low concentrations (typically 0.1-10 ppm depending on application).

The long history of use in food flavoring, combined with the absence of reported adverse events and regulatory recalls, provides practical evidence supporting the safety of this ingredient when used as intended in food manufacturing.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Gamma-heptalactone — Safety, regulation, and evidence." https://additivefacts.com/additives/gamma-heptalactone. Accessed 2026-05-19.