# Dodecyl Propionate

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**Safety rating:** UNKNOWN
**CAS number:** 6221-93-8
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Dodecyl propionate (CAS 6221-93-8) is a synthetic ester compound used as a flavoring agent in food products. It functions as a flavoring adjuvant to enhance or modify taste profiles in various food and beverage applications.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Dodecyl Propionate?

Dodecyl propionate is a synthetic ester compound composed of a twelve-carbon alkyl chain (dodecyl group) bonded to propionic acid. With the CAS number 6221-93-8, this chemical belongs to the ester class of compounds commonly used in the food industry. Esters like dodecyl propionate are created through the chemical reaction between an alcohol and an acid, resulting in compounds that often possess characteristic aromatic or flavoring properties.

## Common Uses

Dodecyl propionate is used as a flavoring agent or flavoring adjuvant in food products. Its primary application involves enhancing, modifying, or supplementing the taste profile of foods and beverages. Like many synthetic flavor compounds, it is utilized in small quantities to achieve desired sensory characteristics. The specific food categories where this compound may be used depend on regional regulatory approvals and manufacturer formulations.

## Safety Assessment

Dodecyl propionate has no reported adverse events in the FDA's database and has not been associated with any FDA recalls. The lack of reported adverse events suggests that any exposure through food consumption has not generated safety concerns significant enough to warrant regulatory action or public health alerts. However, it is important to note that the absence of reported adverse events does not constitute comprehensive safety data, as such reports are dependent on detection, identification, and reporting by healthcare providers and consumers.

Like all food additives, the safety of dodecyl propionate is based on intended use levels, which typically involve minimal quantities. The compound's chemical structure as an ester suggests it may undergo hydrolysis in the digestive system, potentially breaking down into its component parts (dodecanol and propionic acid), both of which have established food industry histories.

## Regulatory Status

Dodecyl propionate is not listed as a Generally Recognized as Safe (GRAS) substance by the FDA. This means it has not received GRAS affirmation through the FDA's official process. However, GRAS status is not a requirement for all food additives; some compounds may be used under FDA approval through different regulatory pathways or in accordance with regulations in specific jurisdictions. The regulatory status varies by country, and approval in one region does not automatically indicate approval elsewhere.

Manufacturers using dodecyl propionate in food products should verify its permissibility under applicable local, state, and federal regulations. International regulations, including those from the European Food Safety Authority (EFSA), may also apply depending on where products are marketed.

## Key Studies

Specific published safety studies on dodecyl propionate appear limited in the readily available scientific literature. The compound's use as a flavoring agent suggests it falls under the category of substances evaluated through flavor industry safety assessment processes. Many synthetic flavoring compounds are evaluated by the Flavor and Extract Manufacturers Association (FEMA) and related bodies that maintain proprietary safety databases.

For flavor compounds generally, toxicological assessments typically evaluate acute toxicity, potential allergenic properties, and metabolic fate. The ester structure of dodecyl propionate suggests it would follow typical ester metabolism pathways. Research on structurally similar compounds and propionic acid derivatives provides indirect safety context, as these have been used in food applications for extended periods.

Additional research and safety documentation may exist within regulatory agency files or proprietary industry records that are not publicly available. Consumers and professionals seeking detailed safety information should consult official regulatory databases, safety data sheets, or contact manufacturers directly for comprehensive documentation.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Dodecyl Propionate — Safety, regulation, and evidence." https://additivefacts.com/additives/dodecyl-propionate. Accessed 2026-05-19.