# Diphenyl Ether (E230)

> Source URL: https://additivefacts.com/additives/diphenyl-ether
> Markdown URL: https://additivefacts.com/additives/diphenyl-ether.md

**Safety rating:** UNKNOWN
**E-number:** E230
**CAS number:** 101-84-8
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Diphenyl ether (CAS 101-84-8) is an organic compound used as a flavoring agent and flavor enhancer in food products. It is not approved as a food additive by the FDA and has not achieved GRAS (Generally Recognized As Safe) status.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Diphenyl Ether?

Diphenyl ether, chemically known as phenyl ether or diphenyl oxide, is an organic compound with the molecular formula C₁₂H₁₀O. It consists of two phenyl groups connected by an oxygen atom. In food applications, it functions as a flavoring agent and flavor enhancer, contributing aromatic properties to food formulations.

## Common Uses

Diphenyl ether has been investigated for use in flavoring applications within the food industry. However, its actual use in commercially available food products in the United States is not widespread due to its regulatory status. Where it may be used, it is typically incorporated in very small quantities to provide or enhance specific flavor profiles. The compound's use is more commonly established in industrial applications outside the food sector, including as a heat transfer medium and in organic synthesis.

## Safety Assessment

The safety profile of diphenyl ether in food applications remains limited due to its lack of FDA approval and GRAS designation. According to FDA records, there have been zero adverse events reported associated with diphenyl ether consumption, and no food recalls have been issued related to this substance. However, the absence of reported adverse events does not necessarily indicate extensive safety testing specific to food use.

Toxicological studies of diphenyl ether conducted in non-food contexts suggest the compound has relatively low acute toxicity. Animal studies have examined potential effects on organ systems, though comprehensive long-term dietary safety data specific to human consumption at food levels is limited. The compound's chemical stability and metabolism in the human body require further characterization for definitive food safety conclusions.

## Regulatory Status

Diphenyl ether is not listed on the FDA's GRAS (Generally Recognized As Safe) inventory for food use, meaning it has not met the regulatory threshold for unrestricted use in food products. The substance is also not approved as a direct food additive under FDA regulations. This regulatory status restricts its legal use in food intended for the U.S. market, though it may be permitted in certain other jurisdictions under different regulatory frameworks.

The European Food Safety Authority (EFSA) has not issued a specific food additive approval for diphenyl ether, further limiting its use in major regulated markets. Manufacturers seeking to use this compound would need to submit a food additive petition to the FDA or equivalent regulatory bodies in other countries, demonstrating safety and necessity for the intended use.

## Key Studies

Limited published research specifically addresses diphenyl ether as a food additive. Most available toxicological data comes from occupational exposure studies and industrial use evaluations rather than dietary consumption studies. These studies generally indicate low acute toxicity, but gaps remain regarding chronic dietary exposure, potential bioaccumulation, and long-term health effects at food-relevant exposure levels.

The lack of GRAS status suggests that either formal safety petitions have not been submitted for this substance, or that submitted data did not meet FDA requirements for approval. Regulatory decisions typically depend on adequate toxicology studies, manufacturing specifications, proposed use levels, and analytical methods for detecting the substance in food—elements that may not be fully developed for food applications of diphenyl ether.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Diphenyl Ether (E230) — Safety, regulation, and evidence." https://additivefacts.com/additives/diphenyl-ether. Accessed 2026-05-19.