# Dimethyl Trisulfide

> Source URL: https://additivefacts.com/additives/dimethyl-trisulfide
> Markdown URL: https://additivefacts.com/additives/dimethyl-trisulfide.md

**Safety rating:** UNKNOWN
**CAS number:** 3658-80-8
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Dimethyl trisulfide is an organic sulfur compound used as a flavoring agent in food manufacturing. It imparts savory, meaty, and sulfurous notes and belongs to a class of volatile compounds commonly found naturally in cooked foods.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Dimethyl Trisulfide?

Dimethyl trisulfide (DMTS) is an organosulfur compound with the chemical formula C₂H₆S₃ and CAS number 3658-80-8. It is a volatile liquid that belongs to the polysulfide family of flavor compounds. This additive is characterized by a strong, pungent sulfurous odor and is used primarily in the flavor industry to create savory, cooked meat-like, and umami flavor profiles in processed foods.

Dimethyl trisulfide occurs naturally in various foods, including cooked beef, roasted coffee, grilled meats, and fermented products. Its presence in these foods contributes significantly to their characteristic flavor and aroma. As a food additive, synthetic dimethyl trisulfide provides manufacturers with the ability to standardize and replicate these complex flavors in a controlled manner.

## Common Uses

Dimethyl trisulfide is utilized as a flavoring agent in several food categories:

- Savory snacks and seasonings
- Meat flavoring compounds and bouillon products
- Soups and broth bases
- Gravy and sauce preparations
- Processed meat products
- Flavor blends for instant foods

The additive is typically used in very small quantities, as its strong flavor intensity means only trace amounts are needed to achieve desired taste profiles. It functions as part of complex flavor systems rather than as a standalone ingredient.

## Safety Assessment

Dimethyl trisulfide has not been formally evaluated for GRAS (Generally Recognized as Safe) status by the FDA, which means it operates in a regulatory gray area in the United States. However, the absence of FDA GRAS status does not necessarily indicate a safety concern—rather, it reflects the specific regulatory pathway and evaluation timeline for this particular compound.

Importantly, there are no reported adverse events associated with dimethyl trisulfide in the FDA's adverse event database, and no product recalls have been issued due to safety concerns with this ingredient. The compound's lack of adverse event reports suggests either its limited use, its safety in food applications, or both.

As a naturally occurring compound in foods, dimethyl trisulfide has a history of exposure through diet. The safe level of intake is influenced by its use concentration, which is typically parts per million or lower in finished food products. Like all flavor compounds, safety depends on the level and frequency of exposure.

## Regulatory Status

In the United States, dimethyl trisulfide is permitted for use as a flavoring substance under the Food Additives Amendment, though it lacks formal GRAS status. This means it can be used in food under the framework of food additives regulations, but manufacturers should ensure appropriate usage levels based on flavor industry standards.

The European Food Safety Authority (EFSA) has included dimethyl trisulfide in its flavor compound evaluations as part of the Flavouring Group Evaluation (FGE) process. In Europe, it is listed under the approved flavoring substances regulations for use in food and beverages.

The compound is recognized by the International Organization for Standardization (ISO) and is used according to the principles established for natural flavoring substances and flavor additives.

## Key Studies

Research on dimethyl trisulfide has primarily focused on its occurrence in foods and its contribution to flavor profiles rather than safety toxicology. Studies examining cooked meat flavor chemistry consistently identify DMTS as a key volatile compound responsible for savory notes. Its volatility and sensory characteristics make it valuable in flavor research.

The compound has been evaluated within broader assessments of organosulfur flavor compounds used in the food industry. Published research indicates that polysulfides like dimethyl trisulfide are metabolized through standard sulfur metabolism pathways in the body, similar to sulfur compounds from naturally-occurring dietary sources.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Dimethyl Trisulfide — Safety, regulation, and evidence." https://additivefacts.com/additives/dimethyl-trisulfide. Accessed 2026-05-19.