# Cis- And Trans-p-1(7),8-menthadien-2-yl Acetate

> Source URL: https://additivefacts.com/additives/cis-and-trans-p-1-7-8-menthadien-2-yl-acetate
> Markdown URL: https://additivefacts.com/additives/cis-and-trans-p-1-7-8-menthadien-2-yl-acetate.md

**Safety rating:** UNKNOWN
**CAS number:** 15111-97-4
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Cis- and trans-p-1(7),8-menthadien-2-yl acetate is a synthetic flavoring compound derived from menthol chemistry. It is used in food and beverage products to provide minty and cooling sensory notes.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Cis- and Trans-p-1(7),8-menthadien-2-yl Acetate?

Cis- and trans-p-1(7),8-menthadien-2-yl acetate (CAS Number: 15111-97-4) is a synthetic organic compound belonging to the class of terpenoid esters. It is a structural derivative of menthol, one of nature's most common flavoring molecules found in peppermint and spearmint plants. This additive exists as a mixture of two isomeric forms—cis and trans—which are mirror-image configurations of the same molecular structure. The acetate ester functional group gives it distinct chemical properties that influence its volatility and flavor profile.

## Common Uses

This flavoring agent is used primarily in the food and beverage industry to impart cooling, minty, and fresh sensory characteristics. It may appear in products such as confectionery items, chewing gums, beverages, dairy products, and oral care foods. Due to its synthetic nature and structural similarity to naturally-derived menthol compounds, it serves as an alternative to natural menthol in applications where consistency, cost-effectiveness, or supply chain considerations favor synthetic options. The compound's dual isomeric composition allows manufacturers to achieve specific flavor profiles tailored to product requirements.

## Safety Assessment

According to FDA records, there are zero reported adverse events associated with this additive and zero recalls involving this compound. The absence of adverse event reports suggests a safety history without documented consumer harm. However, it is important to note that this additive does not currently hold Generally Recognized as Safe (GRAS) status with the FDA, which means it has not undergone the formal GRAS notification process that many food additives complete.

The lack of GRAS status does not inherently indicate a safety concern; rather, it reflects the regulatory pathway through which a substance has been evaluated or authorized. Some additives may be approved through other regulatory mechanisms, such as food additive petitions or international regulatory authorizations. The absence of adverse events and recalls provides supporting evidence for the practical safety profile of this substance in its current uses.

As a menthol-derivative compound, this additive shares structural similarities with widely-accepted flavoring molecules that have long histories of safe use. However, individual risk assessment depends on factors including exposure levels, frequency of consumption, and individual sensitivity to menthol-type compounds. Persons with specific sensitivities to menthol or cooling agents should exercise caution with products containing this ingredient.

## Regulatory Status

The regulatory classification of cis- and trans-p-1(7),8-menthadien-2-yl acetate varies by jurisdiction. In the United States, while it is not GRAS-listed, it may be permitted under specific regulatory pathways or used in products subject to particular approval frameworks. The FDA maintains oversight of this substance as a food additive, and its use must comply with applicable regulations and safety standards.

International regulatory bodies including the European Food Safety Authority (EFSA) and other national food authorities in countries such as Japan and Canada have their own assessment procedures and approval lists. Manufacturers seeking to use this additive in different markets must navigate the distinct regulatory requirements of each jurisdiction.

## Key Studies

Limited peer-reviewed literature specifically addressing this particular isomeric mixture appears in scientific databases, reflecting its specialized use as a flavor compound. Most safety data relevant to this additive derives from general toxicological knowledge of menthol-derivative compounds and acetate ester chemistry. Structural analogs have been extensively studied for safety and flavor properties. The absence of adverse events and recalls in FDA records represents the most directly relevant safety indicator for this specific substance in its practical food applications.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Cis- And Trans-p-1(7),8-menthadien-2-yl Acetate — Safety, regulation, and evidence." https://additivefacts.com/additives/cis-and-trans-p-1-7-8-menthadien-2-yl-acetate. Accessed 2026-05-19.