# Cis- And Trans-l-mercapto-p-menthan-3-one

> Source URL: https://additivefacts.com/additives/cis-and-trans-l-mercapto-p-menthan-3-one
> Markdown URL: https://additivefacts.com/additives/cis-and-trans-l-mercapto-p-menthan-3-one.md

**Safety rating:** UNKNOWN
**CAS number:** 29725-66-4
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Cis- and trans-l-mercapto-p-menthan-3-one is a synthetic flavoring compound that provides minty, cooling, or herbal notes in food and beverage applications. It is not currently approved as Generally Recognized as Safe (GRAS) by the FDA.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Cis- and Trans-l-mercapto-p-menthan-3-one?

Cis- and trans-l-mercapto-p-menthan-3-one (CAS Number 29725-66-4) is a synthetic organic compound belonging to the class of volatile sulfur-containing molecules used in the flavor industry. The compound exists in two isomeric forms—cis and trans—which differ in their spatial molecular arrangement. These structural variations can influence the sensory properties and intensity of the flavoring effect. The compound is chemically derived from menthane, a naturally occurring component in mint plants, with the addition of a thiol group (mercapto) that contributes distinctive sensory characteristics.

## Common Uses

This flavoring agent is used in the food and beverage industry to impart cooling, minty, or herbal flavor notes. It may be incorporated into products such as chewing gum, breath fresheners, candies, beverages, and oral care products. The compound is typically used in very small quantities, as is standard practice with most synthetic flavor compounds. Its specific organoleptic properties make it valuable for formulations requiring distinctive cooling sensations or mint-like profiles. The flavor industry employs this substance as part of complex flavor systems designed to achieve desired taste profiles.

## Safety Assessment

As of current FDA records, there have been zero reported adverse events associated with this additive and zero product recalls linked to its use. The lack of adverse event reports suggests no acute toxicological concerns have been documented in the U.S. food supply. However, the absence of GRAS status indicates that the FDA has not made a formal determination that this substance is generally recognized as safe based on extensive history of use or scientific consensus.

The safety profile of this compound would typically be evaluated based on standard toxicological testing parameters including acute toxicity, genotoxicity, and subchronic/chronic toxicity studies. Sulfur-containing flavor compounds are generally recognized as a class with established safety data; however, individual compounds require specific evaluation.

## Regulatory Status

This additive does not hold FDA GRAS status, meaning it cannot be used in food without specific FDA approval or authorization. In the United States, any use would require either a prior sanctioned status or food additive petition approval. The European Union's flavor compound database and EFSA assessments may provide additional regulatory perspectives on similar compounds in this chemical class.

The lack of GRAS designation does not necessarily indicate safety concerns; rather, it reflects that adequate scientific data demonstrating safe use with a history of consumption was not submitted to or accepted by the FDA. Companies wishing to use this compound in food products would need to submit a food additive petition with supporting safety data.

## Key Studies

Specific published toxicological studies on this exact compound appear limited in the public scientific literature. Safety assessments of similar sulfur-containing menthane derivatives and related flavor compounds provide relevant comparative data. The flavor industry typically relies on:taste threshold data and organoleptic evaluations, standard toxicological testing protocols (OECD guidelines), and comparative safety assessments with structurally similar approved compounds.

The FEMA GRAS program (Flavor and Extract Manufacturers Association) may have evaluated this or related compounds, and such assessments are published in peer-reviewed journals. Interested parties should consult the most current flavor industry safety literature and regulatory databases for comprehensive safety dossiers.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Cis- And Trans-l-mercapto-p-menthan-3-one — Safety, regulation, and evidence." https://additivefacts.com/additives/cis-and-trans-l-mercapto-p-menthan-3-one. Accessed 2026-05-19.