# Cinnamaldehyde Propyleneglycol Acetal

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**Safety rating:** SAFE
**CAS number:** 4353-01-9
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Cinnamaldehyde propyleneglycol acetal is a synthetic flavoring compound derived from cinnamaldehyde, the primary component responsible for cinnamon's distinctive taste and aroma. It is used in food and beverage products to impart cinnamon-like flavoring.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Cinnamaldehyde Propyleneglycol Acetal?

Cinnamaldehyde propyleneglycol acetal (CAS Number: 4353-01-9) is a synthetic organic compound created by reacting cinnamaldehyde with propylene glycol. Cinnamaldehyde is a naturally occurring aldehyde found in cinnamon bark and is responsible for cinnamon's characteristic spicy, warm flavor profile. The propylene glycol acetal formation is a chemical modification that stabilizes and preserves the flavoring compound, making it more suitable for use in processed foods and beverages.

## Common Uses

This flavoring agent is primarily used in the food and beverage industry to provide cinnamon flavoring to various products. Common applications include:

- Baked goods and pastries
- Beverages including soft drinks and coffee products
- Confectionery and candy products
- Flavored dairy products
- Spice blends and seasonings
- Pharmaceutical and supplement formulations

The acetal form offers advantages over natural cinnamaldehyde in terms of stability, shelf life, and consistency in food applications. It allows manufacturers to maintain uniform flavor profiles across production batches.

## Safety Assessment

Cinnamaldehyde propyleneglycol acetal has not been formally affirmed as Generally Recognized as Safe (GRAS) by the FDA. However, the FDA database shows zero reported adverse events and zero recalls associated with this additive, indicating a favorable safety profile in current use.

Both of its primary components have established safety histories. Propylene glycol is widely used in food and pharmaceutical products and is recognized as generally safe. Cinnamaldehyde has a long history of use as a spice and flavoring agent. The combination in acetal form represents a stable, non-reactive compound designed for flavoring purposes.

Cinnamaldehyde compounds in high concentrations have been studied for potential sensory irritation, but typical flavoring levels in food products are well below concentrations that would trigger such effects. Propylene glycol acetals are chemically inert and are not metabolically activated in the body.

## Regulatory Status

In the United States, cinnamaldehyde propyleneglycol acetal is used as a flavoring agent under the regulatory framework for food additives. While it does not have explicit GRAS status from the FDA, it may be used in food under FDA regulations if the manufacturer can document its safety for the intended use, or it may be considered generally recognized as safe based on prior sanction or grandfather status.

The European Union maintains its own flavor compound regulations through the Flavor Regulation (EC) No 1334/2008. Cinnamaldehyde compounds are evaluated for safety through the European Flavour and Extract Manufacturers Association (EFEMA) processes.

Manufacturers using this compound must follow Good Manufacturing Practices and use it in levels that do not exceed those needed to achieve the intended flavoring effect.

## Key Studies

While specific published studies on cinnamaldehyde propyleneglycol acetal are limited, the safety profile is supported by decades of research on both parent compounds. Cinnamaldehyde has been extensively studied for its flavor properties and safety in food applications. Propylene glycol acetal compounds are recognized as chemically stable, non-toxic compounds suitable for food use.

The absence of reported adverse events and recalls in FDA databases, combined with the established safety of component compounds and decades of use, suggests this additive can be considered safe when used as intended for flavoring purposes. As with all food additives, use should be consistent with Good Manufacturing Practices and established usage levels.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Cinnamaldehyde Propyleneglycol Acetal — Safety, regulation, and evidence." https://additivefacts.com/additives/cinnamaldehyde-propyleneglycol-acetal. Accessed 2026-05-19.