# Calcium Diglutamate (E623)

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> Markdown URL: https://additivefacts.com/additives/calcium-diglutamate.md

**Safety rating:** UNKNOWN
**E-number:** E623
**CAS number:** 5996-22-5
**Category:** other
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Calcium diglutamate is a calcium salt of glutamic acid that functions as a food additive, though its specific applications in food products remain largely undocumented. With no reported adverse events or FDA recalls, and minimal regulatory approval data, this additive represents an understudied category in the food safety landscape.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Calcium Diglutamate?

Calcium diglutamate (CAS Number: 5996-22-5) is a chemical compound formed by combining calcium with diglutamic acid, a derivative of glutamic acid. Structurally, it belongs to the family of amino acid salts and glutamate derivatives. Unlike monosodium glutamate (MSG), which is widely used as a flavor enhancer, calcium diglutamate remains a relatively obscure additive with limited commercial documentation and scientific literature describing its properties or applications.

## Common Uses

The specific commercial applications of calcium diglutamate in food products are not well-established in publicly available food industry databases or regulatory documentation. Unlike other glutamate salts that serve recognized functions such as flavor enhancement or umami taste provision, calcium diglutamate's intended purpose in food manufacturing remains unclear. This lack of documented use suggests either minimal commercial adoption or niche applications not widely reported in scientific literature. The additive does not appear in major food additive lists maintained by the FDA or EFSA with clearly defined functional categories.

## Safety Assessment

From a safety perspective, calcium diglutamate presents a limited data profile. The FDA has recorded zero adverse events associated with this additive, and no food recalls have been attributed to its presence in products. This absence of documented harm is notable; however, it may reflect limited market use rather than extensive safety confirmation. The compound's chemical relationship to glutamic acid and approved glutamate salts suggests potential metabolic compatibility, but this assumption requires direct scientific validation rather than structural analogy alone.

As a calcium salt compound, calcium diglutamate could theoretically contribute to calcium intake, though bioavailability and absorption rates specific to this form have not been established in peer-reviewed literature. The absence of published toxicological studies or controlled safety evaluations represents a significant gap in our understanding of this additive's safety profile.

## Regulatory Status

Calcium diglutamate does not hold FDA GRAS (Generally Recognized as Safe) status, which is a critical regulatory distinction. GRAS status requires either a history of safe use in food before 1958 or substantial scientific agreement regarding safety based on adequate testing. The lack of GRAS designation indicates that this additive has not undergone the formal safety review process or does not meet the criteria for such classification.

The additive is not listed in the FDA's Code of Federal Regulations as an approved food additive with an established permitted use. Internationally, the European Food Safety Authority (EFSA) does not maintain prominent documentation of this compound in their approved additives database. This regulatory absence in major markets suggests either that calcium diglutamate is not commercially significant or that its use remains restricted to specific applications or jurisdictions.

## Key Studies

A notable limitation in evaluating calcium diglutamate is the scarcity of peer-reviewed scientific studies specifically investigating its safety, efficacy, or food applications. A search of scientific databases reveals minimal published research dedicated to this particular compound. Most relevant literature focuses on related compounds such as monosodium glutamate, calcium chloride, or other amino acid salts, but direct evidence regarding calcium diglutamate remains sparse.

Without published toxicological studies, acute or chronic toxicity data, or controlled human studies, forming evidence-based conclusions about this additive's safety profile is challenging. The absence of adverse event reports does not constitute affirmative evidence of safety—it may simply reflect lack of use or lack of surveillance.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Calcium Diglutamate (E623) — Safety, regulation, and evidence." https://additivefacts.com/additives/calcium-diglutamate. Accessed 2026-05-19.