# Artichoke Leaves (cynara Scolymus L.)

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**Safety rating:** SAFE
**CAS number:** 977038-45-1
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Artichoke leaves (Cynara scolymus L.) are a plant-derived flavoring agent extracted from the leaves of the common artichoke plant. Used primarily to impart bitter and herbal notes in beverages, foods, and flavor formulations, this ingredient is derived from a botanical source with a long history of culinary use.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Artichoke Leaves?

Artichoke leaves (Cynara scolymus L.) are a botanical flavoring ingredient derived from the edible leaves of the globe artichoke plant, scientifically known as Cynara scolymus L. This ingredient is obtained through extraction or processing of the plant material to concentrate flavor compounds. Artichoke leaves contain naturally occurring compounds including chlorogenic acid, caffeic acid, inulin, and various polyphenols that contribute to the plant's characteristic bitter, slightly sweet, and herbal flavor profile. As a plant-derived flavoring agent, artichoke leaves fall within the broader category of botanical flavorings used in food manufacturing.

## Common Uses

Artichoke leaf flavoring is primarily used in the beverage industry, particularly in herbal infusions, digestive bitters, and aperitif-style drinks that traditionally feature artichoke as a key botanical. The ingredient is also utilized in savory food applications, including soups, sauces, and prepared foods where a bitter or herbal note is desired. In some formulations, artichoke leaf extract serves as a flavor adjuvant—a supporting ingredient that enhances or modifies the overall flavor profile of a food product. The ingredient's use reflects centuries of traditional culinary practice in Mediterranean cuisine, where artichoke has been consumed and valued for both nutritional and flavor characteristics.

## Safety Assessment

Artichoke leaves have not been designated as GRAS (Generally Recognized as Safe) by the FDA, meaning they have not undergone the formal GRAS notification process. However, this classification does not indicate safety concerns; rather, it reflects that formal GRAS petitions have not been submitted to the FDA for this specific ingredient in its flavoring capacity. The absence of reported adverse events and recalls in FDA databases indicates no documented safety issues associated with this flavoring agent in commercial food use. Artichoke, as a vegetable consumed directly in food for centuries across multiple cultures, has an established history of safe consumption. When used as a flavoring agent in typical food applications, the concentration would be substantially lower than in traditional culinary consumption.

Individuals with known allergies to plants in the Asteraceae family (which includes artichokes) should exercise caution, as cross-reactivity is possible. As with any plant-derived ingredient, potential contaminants or pesticide residues depend on agricultural practices and processing standards employed by manufacturers.

## Regulatory Status

Artichoke leaf flavoring is not specifically listed on the FDA's Color Additives Status List or the Established List of GRAS substances. It is permitted for use in foods under FDA regulations as a flavoring agent, provided it complies with general food additive regulations and does not exceed levels that would make health claims. The ingredient's regulatory pathway is governed under 21 CFR § 101.22 (flavoring regulations) rather than requiring pre-market approval. In the European Union, artichoke leaf extract is recognized and permitted as a flavoring substance in food applications. The CAS Number 977038-45-1 provides a unique chemical identifier for regulatory and tracking purposes in international commerce.

## Key Studies

Scientific literature on artichoke constituents has documented the bioactive compounds present in artichoke leaves, including polyphenolic compounds with antioxidant properties. However, research has primarily focused on artichoke extract as a nutritional supplement rather than as a food flavoring at typical use concentrations. Studies on artichoke consumption have not identified specific safety concerns at levels relevant to flavoring applications. Toxicological research on artichoke and its components, conducted in the context of supplement and food ingredient evaluation, has not raised red flags for use as a flavoring agent in standard food applications.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Artichoke Leaves (cynara Scolymus L.) — Safety, regulation, and evidence." https://additivefacts.com/additives/artichoke-leaves-cynara-scolymus-l. Accessed 2026-05-12.