# Angostura, Extract (galipea Officinalis Hancock)

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**Safety rating:** UNKNOWN
**CAS number:** 68916-12-1
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

Angostura Extract is a flavoring agent derived from the bark of Galipea officinalis, a South American tree. It is used in food and beverages to provide bitter, aromatic flavor characteristics, most commonly in cocktails and bitters formulations.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is Angostura Extract?

Angostura Extract, scientifically derived from Galipea officinalis Hancock (also known as angostura bark or cusco bark), is a natural flavoring ingredient obtained from the dried bark of a tree native to South America, particularly Venezuela and other Andean regions. The extract contains volatile oils and bitter compounds that contribute distinctive aromatic and bitter taste notes. The CAS number 68916-12-7 identifies this specific ingredient in chemical databases.

## Common Uses

Angostura Extract is primarily used as a flavoring agent in the beverage industry, with its most well-known application in aromatic bitters—a traditional ingredient in cocktails and mixed drinks. The extract provides complex bitter and spicy flavor notes that enhance the overall taste profile of various spirits and non-alcoholic beverages. It is also utilized in some food products where bitter or herbal flavor enhancement is desired. The ingredient functions both as a flavoring agent and flavor enhancer, contributing to the sensory profile of finished products rather than providing nutritional value.

## Safety Assessment

According to FDA records, there are no reported adverse events associated with Angostura Extract, and no food recalls have been attributed to this ingredient. However, it is important to note that this ingredient is not on the FDA's Generally Recognized as Safe (GRAS) list, which means it has not undergone the formal GRAS notification process or approval.

The absence of GRAS status does not necessarily indicate safety concerns; rather, it reflects that the ingredient may fall under different regulatory categories or that formal GRAS documentation has not been submitted to the FDA. Traditional use in beverages, particularly in bitters formulations that have been consumed for centuries, suggests a historical safety profile, though this does not replace modern safety evaluations.

Like many natural botanical extracts, Angostura contains various phytochemicals. Individual sensitivity to botanical ingredients can vary, and some individuals may experience reactions to concentrated extracts. The ingredient is typically used in small quantities in final food products, which may reduce exposure concerns.

## Regulatory Status

In the United States, Angostura Extract is permitted for use as a flavoring ingredient under FDA regulations for food additives, though it operates under the regulatory framework for flavoring substances rather than GRAS-approved ingredients. This means manufacturers using this ingredient must ensure compliance with general food safety requirements and proper labeling.

The ingredient is recognized in various international food additive databases and is used in food manufacturing in multiple countries, though specific regulatory classifications may vary by jurisdiction. In the European Union, botanical extracts used as flavorings are subject to the Flavoring Regulation, which establishes safety and purity standards.

## Key Studies

Limited published scientific literature specifically addresses the safety profile of commercial Angostura Extract as a food additive. Most research on Galipea officinalis focuses on traditional medicinal uses and phytochemical composition rather than food safety assessments. The chemical composition of the extract includes volatile oils such as limonene, pinene, and various bitter compounds.

Historical data from the long-standing use of angostura bitters in beverages provides observational evidence of safety at typical consumption levels. However, formal toxicological studies specifically evaluating the food additive form of this extract at defined doses are not readily available in peer-reviewed literature.

For manufacturers and consumers seeking additional information, consultation with the FDA or review of specific product safety documentation may provide more detailed assessment data for particular commercial formulations.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "Angostura, Extract (galipea Officinalis Hancock) — Safety, regulation, and evidence." https://additivefacts.com/additives/angostura-extract-galipea-officinalis-hancock. Accessed 2026-05-12.