# 2-methyl-4,5-benzoxazole

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**Safety rating:** UNKNOWN
**CAS number:** 95-21-6
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

2-methyl-4,5-benzoxazole is a synthetic aromatic compound used as a flavoring agent in food products. It imparts nutty, roasted, and bread-like flavor notes and is employed in trace amounts in various processed foods and beverages.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is 2-methyl-4,5-benzoxazole?

2-methyl-4,5-benzoxazole is a heterocyclic aromatic compound classified as a synthetic flavoring agent. With the CAS number 95-21-6, it belongs to the benzoxazole family of chemicals. This compound is characterized by a benzene ring fused to an oxazole ring with a methyl group at the 2-position. It is a white to off-white crystalline solid with a characteristic roasted, nutty aroma.

## Common Uses

In the food industry, 2-methyl-4,5-benzoxazole is used primarily as a flavoring agent to enhance or create specific taste profiles. Its aromatic properties make it suitable for applications in:

- Baked goods and bread products
- Coffee and tea beverages
- Chocolate and cocoa-based products
- Nuts and roasted food flavoring
- Processed snack foods
- Savory food applications

The compound is used in very small quantities, typically measured in parts per million (ppm), to achieve the desired flavor impact without overwhelming other taste components.

## Safety Assessment

According to FDA records, there have been no reported adverse events associated with 2-methyl-4,5-benzoxazole, and no food recalls have been linked to this additive. This lack of adverse event reporting suggests a favorable safety profile in current food applications.

The compound's safety profile is supported by its use at extremely low concentrations in finished food products. Flavoring agents of this type are designed for use at minimal levels where sensory impact is achieved without significant dietary exposure.

Toxicological data on 2-methyl-4,5-benzoxazole is limited in publicly available literature compared to more commonly used additives. However, the absence of documented adverse events in FDA records and its continued use in food applications suggests acceptable safety at current usage levels.

As with many synthetic flavoring agents, safety assessment relies on the principle of using minimal effective quantities to achieve desired sensory outcomes, thereby limiting potential dietary exposure.

## Regulatory Status

2-methyl-4,5-benzoxazole is not on the FDA's Generally Recognized As Safe (GRAS) list. This designation means the compound has not undergone the formal GRAS review process with the FDA. However, its absence from the GRAS list does not indicate unsafe status—rather, it means formal safety documentation and review by FDA experts has not been completed or submitted.

The compound may be used in food under the FDA's food additive regulations if appropriate safety data have been provided to the agency. Many flavoring agents function within the food supply without GRAS status when manufacturers maintain compliance with applicable regulations.

International regulatory approaches to this flavoring agent may vary. Some countries may have different approval statuses or usage restrictions based on their own food safety assessments and regulatory frameworks.

## Key Studies

Published scientific literature specifically addressing 2-methyl-4,5-benzoxazole is limited. Most information about this compound comes from:

- Flavor chemistry and sensory science literature documenting its aromatic properties
- Industrial safety data sheets and manufacturer specifications
- FDA additive petition files and regulatory documentation
- General toxicology references for benzoxazole class compounds

The lack of extensive published research is not uncommon for specialized flavoring agents used at very low concentrations. Safety assessments for such compounds often rely on structural similarity to studied compounds, conservative usage levels, and absence of adverse event reports in the marketplace.

For the most current and detailed safety information, direct consultation with FDA records, manufacturer safety documentation, or formal food additive petitions would provide specific toxicological data submitted for regulatory review.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "2-methyl-4,5-benzoxazole — Safety, regulation, and evidence." https://additivefacts.com/additives/2-methyl-4-5-benzoxazole. Accessed 2026-05-19.