# 2-hexylthiophene

> Source URL: https://additivefacts.com/additives/2-hexylthiophene
> Markdown URL: https://additivefacts.com/additives/2-hexylthiophene.md

**Safety rating:** UNKNOWN
**CAS number:** 18794-77-9
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

2-Hexylthiophene is a synthetic flavoring compound used to impart savory, meaty, and roasted notes to processed foods. It belongs to a class of heterocyclic compounds designed to enhance or modify food taste profiles.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is 2-Hexylthiophene?

2-Hexylthiophene (CAS Number: 18794-77-9) is a synthetic organic compound classified as a flavoring agent or adjuvant. It consists of a thiophene ring—a five-membered aromatic ring containing sulfur—with a hexyl (six-carbon) alkyl chain attached. This structure gives the compound its characteristic aromatic properties and flavor-active characteristics.

As a member of the thiophene family of flavor compounds, 2-hexylthiophene is engineered to provide specific sensory notes to food products, primarily savory, meaty, and roasted flavors that enhance consumer appeal.

## Common Uses

2-Hexylthiophene is utilized in the flavor industry as a food additive to enhance or create complex flavor profiles in processed food products. Its primary applications include:

- Meat and savory-flavored snacks
- Soups and broths
- Seasoning blends
- Ready-to-eat meals
- Savory baked goods and crackers
- Meat analog and plant-based protein products

The compound is typically used in very small quantities, as is standard with flavor compounds, to achieve the desired sensory impact without overwhelming other taste components.

## Safety Assessment

2-Hexylthiophene has not been formally listed as Generally Recognized as Safe (GRAS) by the FDA. However, it carries a notably clean safety record based on available data:

- **Adverse Events**: No adverse events have been reported to the FDA related to this additive
- **Recalls**: No FDA recalls involving 2-hexylthiophene have been documented
- **Reported Incidents**: Zero confirmed negative health incidents in the FDA database

The absence of reported adverse events and recalls suggests that any exposure through food consumption has not resulted in identifiable public health concerns. Like many synthetic flavor compounds, 2-hexylthiophene undergoes safety evaluation based on its chemical structure, proposed use levels, and exposure assessments.

Flavor compounds in this category are typically evaluated for potential toxicity, allergenicity, and metabolic fate. The thiophene structural class has been studied for various compounds, with safety profiles generally considered acceptable at food-use levels.

## Regulatory Status

2-Hexylthiophene's regulatory status reflects its specialized use in the flavor industry:

- **United States**: Not on the FDA's GRAS list, but permitted for use under FDA flavor regulations (21 CFR Part 182) as a synthetic flavoring substance when used in accordance with good manufacturing practices
- **Usage Restrictions**: As with all flavor compounds, its use must comply with Current Good Manufacturing Practice (CGMP) standards and cannot exceed levels necessary to achieve the intended flavoring effect
- **International Status**: Regulatory acceptance varies by country; some nations may have different classifications or restrictions

The compound's non-GRAS status does not necessarily indicate safety concerns but rather reflects the specific pathway by which it was approved for use as a flavor ingredient.

## Key Studies

While 2-hexylthiophene is not extensively studied in published scientific literature compared to more common food additives, its safety evaluation typically follows established protocols for synthetic flavor compounds:

- Flavor compounds are assessed using Structure-Activity Relationship (SAR) analysis to predict potential hazards
- The thiophene class of compounds has been evaluated for mutagenic and toxic potential in various scientific contexts
- Exposure assessments consider typical use levels and the resulting dietary intake
- The compound's chemical stability and metabolic breakdown are considered relevant to safety evaluation

The lack of reported adverse events and recalls suggests that real-world exposure at permitted use levels has not generated detectable safety signals. As with many flavor ingredients used at extremely low concentrations, large-scale epidemiological studies are not typically conducted.

Manufacturers and flavor houses are responsible for maintaining safety data and documentation supporting the use of such compounds in food products.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "2-hexylthiophene — Safety, regulation, and evidence." https://additivefacts.com/additives/2-hexylthiophene. Accessed 2026-05-19.