# 2-ethyl-3-methylthiopyrazine

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**Safety rating:** UNKNOWN
**CAS number:** 72987-62-3
**Category:** flavoring
**FDA GRAS:** no
**Adverse events (FDA AERS):** 0
**FDA recalls:** 0
**Last updated:** 2026-04-02

## Summary

2-ethyl-3-methylthiopyrazine is a synthetic flavoring compound that belongs to the thiopyrazine class of chemicals. It is used in food manufacturing to provide savory, nutty, and roasted flavor notes in various processed foods and beverages.

## Regulatory status

| Country | Status |
| --- | --- |
| United States | approved |
| European Union | not_evaluated |
| United Kingdom | not_evaluated |
| Canada | not_evaluated |
| Australia | not_evaluated |
| Japan | not_evaluated |
| South Korea | not_evaluated |
| Brazil | not_evaluated |
| China | not_evaluated |
| India | not_evaluated |

## Detailed analysis

## What is 2-ethyl-3-methylthiopyrazine?

2-ethyl-3-methylthiopyrazine (CAS Number: 72987-62-3) is a synthetic organic compound classified as a flavoring agent. It belongs to the thiopyrazine family of chemicals, which are heterocyclic compounds containing nitrogen and sulfur atoms in a six-membered ring structure. The specific molecular structure includes an ethyl group and a methyl group attached to the thiopyrazine ring. This compound is produced through chemical synthesis for use exclusively as a food flavoring adjuvant.

## Common Uses

As a flavoring agent, 2-ethyl-3-methylthiopyrazine is used in small quantities to enhance or create specific flavor profiles in processed foods. Thiopyrazine compounds are particularly valued for imparting savory, roasted, and nutty notes that naturally occur in cooked and fermented foods. These flavors are commonly sought in products such as snack foods, seasonings, soups, sauces, meat analogs, and savory beverage applications. The compound functions as a flavoring adjuvant, meaning it works synergistically with other flavor components to create complex taste experiences. Due to its potent flavor profile, only minute quantities are required to achieve the desired effect in finished food products.

## Safety Assessment

Limited published safety data is available for this specific compound in the peer-reviewed literature. According to FDA records, there have been zero reported adverse events associated with 2-ethyl-3-methylthiopyrazine and zero product recalls involving this ingredient. The absence of adverse event reports and recalls suggests no identified safety concerns have emerged from its use in commerce. However, the lack of extensive published safety studies means comprehensive toxicological data may be limited. Safety assessments for synthetic flavoring agents typically consider acute toxicity, potential genotoxicity, and metabolic pathways. General toxicological data for thiopyrazine compounds suggests relatively low acute toxicity, though individual compound profiles vary. Any safety evaluation for this specific compound would typically follow established protocols used for synthetic flavoring substance assessment.

## Regulatory Status

2-ethyl-3-methylthiopyrazine is not on the FDA's Generally Recognized As Safe (GRAS) list. This designation means it has not undergone the formal GRAS notification process or has not been affirmed through regulation as safe for its intended use in food. However, not being GRAS does not necessarily indicate a safety concern; rather, it reflects regulatory classification and notification status. In the United States, synthetic flavoring substances must be approved food additives, and their use must comply with FDA regulations. The European Food Safety Authority (EFSA) maintains separate assessments for food additives approved in the European Union. Regulatory status varies by jurisdiction, and manufacturers must ensure compliance with local food additive regulations where products are marketed.

## Key Studies

Limited published scientific literature specifically addresses 2-ethyl-3-methylthiopyrazine. General safety information for thiopyrazine-class flavoring compounds comes from broader chemical family assessments and flavor industry databases such as the Flavor and Extract Manufacturers Association (FEMA) and the International Organization of the Flavor Industry (IOFI). These organizations maintain flavor ingredient databases that compile available safety data. Additional information may be found in manufacturers' technical documentation and confidential safety dossiers submitted to regulatory authorities. Researchers interested in this compound's properties may consult chemical databases, flavor chemistry literature, and regulatory submissions for available toxicological and metabolic data.

## Sources

- FDA Substances Added to Food (CFSAN)
- OpenFDA Adverse Event Reporting System (AERS)
- OpenFDA Food Recalls
- EFSA OpenFoodTox
- EU Food Additive Portal

## Citation

Additive Facts. "2-ethyl-3-methylthiopyrazine — Safety, regulation, and evidence." https://additivefacts.com/additives/2-ethyl-3-methylthiopyrazine. Accessed 2026-05-19.